Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

Matthew Glen Robertson, Benjamin Bruce Eidenschink, Eriko Iguchi, Stanislav O. Zakharkin, Christopher J. LaRocca, Ezequiel J. Tolosa, Mark J. Truty, Kari Jacobsen, Martin E. Fernandez-Zapico, Julia Davydova

Research output: Contribution to journalArticlepeer-review

Abstract

Sodium iodide symporter (NIS)-expressing oncolytic viruses enable tumor-specific imaging and radiotherapy for infected tumors. We designed a novel NIS-expressing adenoviral vector with deletion of the adenovirus death protein (ADP) gene. ADP deletion improved NIS expression and subsequent imaging capabilities highlighting the role of vector design in effective transgene expression.

Original languageEnglish (US)
Pages (from-to)659-668
Number of pages10
JournalMolecular Therapy - Oncolytics
Volume20
DOIs
StatePublished - Mar 26 2021

Bibliographical note

Funding Information:
This study was supported by NIH NCI R01CA174861 (J.D. and M.E.F.-Z.); NIH NCI R01CA228760 (J.D.); NIH NCI P50CA101955 UAB-UMN Pancreatic Cancer SPORE Career Development Award (J.D.); University of Minnesota Masonic Cancer Center CRTI Translational Research Award grant (J.D. and M.G.R.); and Randy Shaver Cancer Research Grant (J.D. and M.G.R.). The authors thank Drs. John Morris (Mayo Clinic) and Lisa Koodie (UMN) for valuable discussions and technical support.

Publisher Copyright:
© 2021 The Authors

Keywords

  • Adenovirus
  • Adenovirus Death Protein
  • Cancer imaging
  • Oncolytic Virus
  • Pancreatic cancer
  • Radiotherapy
  • Sodium-iodide symporter

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