Sodium iodide symporter (NIS)-expressing oncolytic viruses enable tumor-specific imaging and radiotherapy for infected tumors. We designed a novel NIS-expressing adenoviral vector with deletion of the adenovirus death protein (ADP) gene. ADP deletion improved NIS expression and subsequent imaging capabilities highlighting the role of vector design in effective transgene expression.
Bibliographical noteFunding Information:
This study was supported by NIH NCI R01CA174861 (J.D. and M.E.F.-Z.); NIH NCI R01CA228760 (J.D.); NIH NCI P50CA101955 UAB-UMN Pancreatic Cancer SPORE Career Development Award (J.D.); University of Minnesota Masonic Cancer Center CRTI Translational Research Award grant (J.D. and M.G.R.); and Randy Shaver Cancer Research Grant (J.D. and M.G.R.). The authors thank Drs. John Morris (Mayo Clinic) and Lisa Koodie (UMN) for valuable discussions and technical support.
© 2021 The Authors
- Adenovirus Death Protein
- Cancer imaging
- Oncolytic Virus
- Pancreatic cancer
- Sodium-iodide symporter