@inproceedings{c26472b2791d4151b01bae31a9704db9,
title = "Cancer cell assays by use of immunocapture, subcellular imaging, and programmed cell release in gedi microdevices",
abstract = "We report the use of Geometrically Enhanced Differential Immunocapture (GEDI) μdevices, which employ staggered obstacle arrays functionalized with a prostate-specific antibody, to capture and analyze prostate cancer cells on chip. GE-DI μdevices have been demonstrated to have high capture efficiency and purity [2] as compared similar devices found in the literature [4]. GEDI μdevices have been used to isolate cells from cancer patient samples and are used herein to carry out in situ chemotherapeutic efficacy experiments with a model cell line, simulating a point-of-care diagnostics situation. In addition, we also demonstrate release of captured prostate cancer cells using desthiobiotin and standard antibody conjugation chemistry.",
keywords = "Cell capture, Circulating tumor cells, Immunocapture, Point-of-care diagnotic",
author = "Gleghorn, {Jason P.} and Santana, {Steven M.} and Pratt, {Erica D.} and Loftus, {Matthew S.} and Mona Jodari-Karimi and Bander, {Neil H.} and Nanus, {David M.} and Paraskevi Giannakakou and Kirby, {Brian J.}",
year = "2010",
language = "English (US)",
isbn = "9781618390622",
series = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
pages = "1415--1417",
booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
note = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 ; Conference date: 03-10-2010 Through 07-10-2010",
}
