Can ultrasound be used to estimate bone mineral density in children with growth problems?

Khalid M. Khan, Kyriakie M Sarafoglou, Arif Somani, Brigitte Frohnert, Bradley S Miller

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Abstract

Aim To assess predictability of bone mineral density (BMD) of the lumbar spine (LS) determined by dual-energy x-ray absorptiometry (DXA) using by ultrasound speed of sound of the right and left radii (SOS-R and SOS-L) in patients with growth problems. Methods Ultrasound and DXA were compared in patients with advanced, normal and delayed bone ages assessed by Greulich and Pyle (GP) and Tanner and Whitehouse (TW3) methods. Results There was a strong correlation (r), of raw scores, between SOS-R and SOS-L, r = 0.81, p = 0.000 and their respective Z-scores, r = 0.78, p = 0.000. Z-score correlations were poor between SOS-R or SOS-L and LS-BMD. Sensitivity, specificity, positive and negative predictive values of SOS-R and Z-scores for predicting normal (>-1 to <1) and low (<-1) LS-BMD were poor. For high (>1) LS-BMD, Z-scores were 22%, 93%, 29% and 90%, respectively, for SOS-R and for SOS-L, 25%, 89%, 20% and 91%. For very low (<-2) LS-BMD, SOS-R and SOS-L were the same, respectively, 29%, 91%, 40% and 86%. Conclusion Ultrasound of the radius is a poor predictor of radiologically assessed BMD at the LS, especially with delayed bone age.

Original languageEnglish (US)
JournalActa Paediatrica, International Journal of Paediatrics
Volume102
Issue number9
DOIs
StatePublished - Sep 1 2013

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Bone Density
Spine
Growth
X-Rays
Bone and Bones
Sensitivity and Specificity

Keywords

  • Delayed bone age
  • Dual-energy x-ray absorptiometry
  • Growth
  • Radial ultrasound

Cite this

@article{4e9f4603299c42208c4d278ea40349f4,
title = "Can ultrasound be used to estimate bone mineral density in children with growth problems?",
abstract = "Aim To assess predictability of bone mineral density (BMD) of the lumbar spine (LS) determined by dual-energy x-ray absorptiometry (DXA) using by ultrasound speed of sound of the right and left radii (SOS-R and SOS-L) in patients with growth problems. Methods Ultrasound and DXA were compared in patients with advanced, normal and delayed bone ages assessed by Greulich and Pyle (GP) and Tanner and Whitehouse (TW3) methods. Results There was a strong correlation (r), of raw scores, between SOS-R and SOS-L, r = 0.81, p = 0.000 and their respective Z-scores, r = 0.78, p = 0.000. Z-score correlations were poor between SOS-R or SOS-L and LS-BMD. Sensitivity, specificity, positive and negative predictive values of SOS-R and Z-scores for predicting normal (>-1 to <1) and low (<-1) LS-BMD were poor. For high (>1) LS-BMD, Z-scores were 22{\%}, 93{\%}, 29{\%} and 90{\%}, respectively, for SOS-R and for SOS-L, 25{\%}, 89{\%}, 20{\%} and 91{\%}. For very low (<-2) LS-BMD, SOS-R and SOS-L were the same, respectively, 29{\%}, 91{\%}, 40{\%} and 86{\%}. Conclusion Ultrasound of the radius is a poor predictor of radiologically assessed BMD at the LS, especially with delayed bone age.",
keywords = "Delayed bone age, Dual-energy x-ray absorptiometry, Growth, Radial ultrasound",
author = "Khan, {Khalid M.} and Sarafoglou, {Kyriakie M} and Arif Somani and Brigitte Frohnert and Miller, {Bradley S}",
year = "2013",
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doi = "10.1111/apa.12314",
language = "English (US)",
volume = "102",
journal = "Acta Paediatrica, International Journal of Paediatrics",
issn = "0803-5253",
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TY - JOUR

T1 - Can ultrasound be used to estimate bone mineral density in children with growth problems?

AU - Khan, Khalid M.

AU - Sarafoglou, Kyriakie M

AU - Somani, Arif

AU - Frohnert, Brigitte

AU - Miller, Bradley S

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Aim To assess predictability of bone mineral density (BMD) of the lumbar spine (LS) determined by dual-energy x-ray absorptiometry (DXA) using by ultrasound speed of sound of the right and left radii (SOS-R and SOS-L) in patients with growth problems. Methods Ultrasound and DXA were compared in patients with advanced, normal and delayed bone ages assessed by Greulich and Pyle (GP) and Tanner and Whitehouse (TW3) methods. Results There was a strong correlation (r), of raw scores, between SOS-R and SOS-L, r = 0.81, p = 0.000 and their respective Z-scores, r = 0.78, p = 0.000. Z-score correlations were poor between SOS-R or SOS-L and LS-BMD. Sensitivity, specificity, positive and negative predictive values of SOS-R and Z-scores for predicting normal (>-1 to <1) and low (<-1) LS-BMD were poor. For high (>1) LS-BMD, Z-scores were 22%, 93%, 29% and 90%, respectively, for SOS-R and for SOS-L, 25%, 89%, 20% and 91%. For very low (<-2) LS-BMD, SOS-R and SOS-L were the same, respectively, 29%, 91%, 40% and 86%. Conclusion Ultrasound of the radius is a poor predictor of radiologically assessed BMD at the LS, especially with delayed bone age.

AB - Aim To assess predictability of bone mineral density (BMD) of the lumbar spine (LS) determined by dual-energy x-ray absorptiometry (DXA) using by ultrasound speed of sound of the right and left radii (SOS-R and SOS-L) in patients with growth problems. Methods Ultrasound and DXA were compared in patients with advanced, normal and delayed bone ages assessed by Greulich and Pyle (GP) and Tanner and Whitehouse (TW3) methods. Results There was a strong correlation (r), of raw scores, between SOS-R and SOS-L, r = 0.81, p = 0.000 and their respective Z-scores, r = 0.78, p = 0.000. Z-score correlations were poor between SOS-R or SOS-L and LS-BMD. Sensitivity, specificity, positive and negative predictive values of SOS-R and Z-scores for predicting normal (>-1 to <1) and low (<-1) LS-BMD were poor. For high (>1) LS-BMD, Z-scores were 22%, 93%, 29% and 90%, respectively, for SOS-R and for SOS-L, 25%, 89%, 20% and 91%. For very low (<-2) LS-BMD, SOS-R and SOS-L were the same, respectively, 29%, 91%, 40% and 86%. Conclusion Ultrasound of the radius is a poor predictor of radiologically assessed BMD at the LS, especially with delayed bone age.

KW - Delayed bone age

KW - Dual-energy x-ray absorptiometry

KW - Growth

KW - Radial ultrasound

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U2 - 10.1111/apa.12314

DO - 10.1111/apa.12314

M3 - Article

VL - 102

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

SN - 0803-5253

IS - 9

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