Can phenytoin lower plasma fibrinogen concentrations?

Chris Goerdt, Hanna Bloomfield Rubins, William Swaim, Aaron Folsom

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A strong, independent and positive association between plasma fibrinogen concentrations and cardiovascular disease has been established. To determine if phenytoin lowers fibrinogen levels we measured plasma fibrinogen levels in a subset of participants enrolled in arandomized, placebo-controlled, double-blind clinical trial. Participants received placebo or 100 mg, 200 mg, or 300 mg/day of phenytoin for 14 weeks. Fifty-six subjects had post-treatment and 20 had pre- and post-treatment fibrinogen measurements. The phenytoin-treated subjects with post-treatment measurements had a 0.24 g/l (8%) reduction in mean fibrinogen levels compared to placebo (p=0.3). Phenytoin may be capable of producing meaningful reductions in fibrinogen levels.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalThrombosis Research
Issue number3
StatePublished - Aug 1 1995


  • cardiovascular diseases
  • fibrinogen
  • phenytoin


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