Can G-CSF cause leukemia in hematopoietic stem cell donors?

Belinda R. Avalos, Aleksandr Lazaryan, Edward A. Copelan

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

A large majority of allogeneic hematopoietic stem cell donations are achieved using granulocyte-colony stimulating factor (G-CSF). G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances. Although clinical data to date have failed to identify any increased incidence of MDS/AML in G-CSF mobilized donors, the quality of these data are insufficient to exclude a long-term risk. Physicians should explain the potential risk to donors, and where appropriate, offer donors the option of marrow donation.

Original languageEnglish (US)
Pages (from-to)1739-1746
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Volume17
Issue number12
DOIs
StatePublished - Dec 2011

Keywords

  • G-CSF
  • Peripheral blood progenitor cell mobilization
  • Stem cell donors

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