Can abdominal computed tomography imaging help accurately identify a dedifferentiated component in a well-differentiated liposarcoma?

Priya Bhosale, Jieqi Wang, Datla Varma, Corey Jensen, Madhavi Patnana, Wei Wei, Anil Chauhan, Barry Feig, Shreyaskumar Patel, Neeta Somaiah, Tara Sagebiel

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Purpose: To assess the ability of computed tomography (CT) to differentiate an atypical lipomatous tumor/well-differentiated liposarcoma (WDLPS) from a WDLPS with a dedifferentiated component (DDLPS) within it. Materials and Methods: Forty-nine untreated patients with abdominal atypical lipomatous tumors/well-differentiated liposarcomas who had undergone contrast-enhanced CTwere identified using an institutional database. Three radiologists who were blinded to the pathology findings evaluated all the images independently to determine whether a dedifferentiated component was present within the WDLPS. The CT images were evaluated for fat content (?25% or >25%); presence of groundglass density, enhancing and/or necrotic nodules; presence of a capsule surrounding the mass; septations; and presence and pattern of calcifications. A multivariate logistic regression model with generalized estimating equations was used to correlate imaging features with pathology findings. Kappa statistics were calculated to assess agreement between the three radiologists. Results: On the basis of pathological findings, 12 patients had been diagnosed with DDLPS within a WDLPS and 37 had been diagnosed with WDLPS. The presence of an enhancing or a centrally necrotic nodule within the atypical lipomatous tumor was associated with dedifferentiated liposarcoma (P = 0.02 and P = 0.0003, respectively). The three readers showed almost perfect agreement in overall diagnosis (? r= 0.83; 95%confidence interval, 0.67-0.99). Conclusions: An enhancing or centrally necrotic nodule may be indicative of a dedifferentiated component in well-differentiated liposarcoma. Ground-glass density nodules may not be indicative of dedifferentiation.

Original languageEnglish (US)
Pages (from-to)872-879
Number of pages8
JournalJournal of computer assisted tomography
Issue number6
StatePublished - 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.


  • Contrast enhanced CT
  • Dedifferentiated liposarcoma
  • Enhancement pattern
  • Liposarcoma
  • Well differentiated liposarcoma


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