Calmodulin levels in diabetic mice

J. E. Morley; A. S. Levine; D. M. Brown; B. S. Handwerger

doi:10.1016/S0006-291X(82)80065-X

Calmodulin levels in diabetic mice

J. E. Morley, A. S. Levine, D. M. Brown, B. S. Handwerger

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Calcium has been considered to play a role as an intracellular mediator for insulin. Many of the intracellular effects of calcium are mediated through calcium binding proteins, the most important of which is calmodulin. In this study we have demonstrated elevated levels of calmodulin as measured by radioimmunoassay in the abdominal fat, muscle, kidney and heart but not in the liver of streptozotocin-induced diabetic mice compared to their controls. Elevated calmodulin levels were also demonstrated in the kidney and heart of genetically obese, diabetic mice (C57 BL/Ks db+/db+) compared to both their heterozygote (db/m) and homozygote (m/m) controls.

Original language	English (US)
Pages (from-to)	1418-1423
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	108
Issue number	4
DOIs	https://doi.org/10.1016/S0006-291X(82)80065-X
State	Published - Oct 29 1982
Externally published	Yes

Bibliographical note

Funding Information:
were supported, in part, by grants from the American Diabetes Association

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10.1016/S0006-291X(82)80065-X

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abstract = "Calcium has been considered to play a role as an intracellular mediator for insulin. Many of the intracellular effects of calcium are mediated through calcium binding proteins, the most important of which is calmodulin. In this study we have demonstrated elevated levels of calmodulin as measured by radioimmunoassay in the abdominal fat, muscle, kidney and heart but not in the liver of streptozotocin-induced diabetic mice compared to their controls. Elevated calmodulin levels were also demonstrated in the kidney and heart of genetically obese, diabetic mice (C57 BL/Ks db+/db+) compared to both their heterozygote (db/m) and homozygote (m/m) controls.",

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AU - Morley, J. E.

AU - Levine, A. S.

AU - Brown, D. M.

AU - Handwerger, B. S.

N1 - Funding Information: were supported, in part, by grants from the American Diabetes Association

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Y1 - 1982/10/29

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AB - Calcium has been considered to play a role as an intracellular mediator for insulin. Many of the intracellular effects of calcium are mediated through calcium binding proteins, the most important of which is calmodulin. In this study we have demonstrated elevated levels of calmodulin as measured by radioimmunoassay in the abdominal fat, muscle, kidney and heart but not in the liver of streptozotocin-induced diabetic mice compared to their controls. Elevated calmodulin levels were also demonstrated in the kidney and heart of genetically obese, diabetic mice (C57 BL/Ks db+/db+) compared to both their heterozygote (db/m) and homozygote (m/m) controls.

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Calmodulin levels in diabetic mice

Abstract

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