TY - JOUR
T1 - Calibrated bioresorbable microspheres
T2 - A preliminary study on the level of occlusion and arterial distribution in a rabbit kidney model
AU - Weng, Lihui
AU - Rusten, Myra
AU - Talaie, Reza
AU - Hairani, Mehrdad
AU - Rosener, Nikolaus K.
AU - Golzarian, Jafar
N1 - Funding Information:
This work was supported by a pilot research grant (2011, No. 001612 ) from the Society of Interventional Radiology Foundation .
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/10
Y1 - 2013/10
N2 - Purpose: To assess the level of occlusion and arterial distribution of calibrated bioresorbable microspheres (BRMS-I and BRMS-II) compared with tris-acryl gelatin microspheres (TGMS) after renal embolization. Materials and Methods: Six rabbits underwent renal embolization with 100-300 μm BRMS-I and TGMS; three rabbits received partial occlusion (group 1, n = 3), and three rabbits received total occlusion (group 2, n = 3). Four other rabbits received 100-300 μm BRMS-II (with higher cross-linking density than BRMS-I) in the left kidneys reaching total occlusion (group 3, n = 4). Coronal sections of the kidneys were histologically analyzed. Ease of injection, microsphere deformation, vessel sizes, and arterial distribution were assessed. Results: The injection of BRMS-I, BRMS-II, and TGMS through microcatheters went smoothly without any clogging. In group 1, BRMS identification was easier than TGMS. In group 2, both BRMS-I and TGMS were observed in all three arterial levels (interlobar, arcuate, and interlobular arteries) without a significant difference (P =.84). BRMS-I were not significantly different from TGMS in the mean diameter of vessels occluded (197 μm ± 23 vs 158 μm ± 21, P =.25) or the microsphere deformation (8.85% ± 0.53% vs 11.80% ± 0.64%, P =.071). In group 3, the arterial distribution of BRMS-II was significantly different from BRMS-I and TGMS (P <.0001). Conclusions: In occluding arteries, 100-300 μm BRMS-I were not significantly different from 100-300 μm TGMS. Arterial distribution of BRMS can be influenced by their cross-linking density.
AB - Purpose: To assess the level of occlusion and arterial distribution of calibrated bioresorbable microspheres (BRMS-I and BRMS-II) compared with tris-acryl gelatin microspheres (TGMS) after renal embolization. Materials and Methods: Six rabbits underwent renal embolization with 100-300 μm BRMS-I and TGMS; three rabbits received partial occlusion (group 1, n = 3), and three rabbits received total occlusion (group 2, n = 3). Four other rabbits received 100-300 μm BRMS-II (with higher cross-linking density than BRMS-I) in the left kidneys reaching total occlusion (group 3, n = 4). Coronal sections of the kidneys were histologically analyzed. Ease of injection, microsphere deformation, vessel sizes, and arterial distribution were assessed. Results: The injection of BRMS-I, BRMS-II, and TGMS through microcatheters went smoothly without any clogging. In group 1, BRMS identification was easier than TGMS. In group 2, both BRMS-I and TGMS were observed in all three arterial levels (interlobar, arcuate, and interlobular arteries) without a significant difference (P =.84). BRMS-I were not significantly different from TGMS in the mean diameter of vessels occluded (197 μm ± 23 vs 158 μm ± 21, P =.25) or the microsphere deformation (8.85% ± 0.53% vs 11.80% ± 0.64%, P =.071). In group 3, the arterial distribution of BRMS-II was significantly different from BRMS-I and TGMS (P <.0001). Conclusions: In occluding arteries, 100-300 μm BRMS-I were not significantly different from 100-300 μm TGMS. Arterial distribution of BRMS can be influenced by their cross-linking density.
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U2 - 10.1016/j.jvir.2013.06.009
DO - 10.1016/j.jvir.2013.06.009
M3 - Article
C2 - 23928298
AN - SCOPUS:84884593613
SN - 1051-0443
VL - 24
SP - 1567
EP - 1575
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 10
ER -