Calcium uptake by cardiac sarcoplasmic reticulum in human dilated cardiomyopathy

Constantinos J. Limas, Maria Teresa Olivari, Irvin F. Goldenberg, T. Barry Levine, David G. Benditt, Ada Simon

Research output: Contribution to journalReview articlepeer-review

146 Scopus citations

Abstract

Summary: To determine the biochemical basis of abnormal diastolic properties in human dilated cardiomyopathy calcium uptake by the sarcoplasmic reticulum in ventricular homogenates of biopsy specimens from 21 patients with dilated cardiomyopathy was compared with that in nine normal controls. As a group, patients with cardiomyopathy had considerably lower calcium uptake rates (3.3(0.6) nmol·mg-1·min-1 vs 6.5(0.5) nmol·mg-1·min-1, p<0.01). Calcium uptake rates correlated modestly with resting haemodynamic values and significantly with plasma noradrenaline concentrations but not with plasma renin activity. These results show that sarcoplasmic reticulum function is impaired in human dilated cardiomyopathy and that this impairment is related both to the severity of haemodynamic dysfunction and to the extent of sympathetic nervous system activation.

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
JournalCardiovascular Research
Volume21
Issue number8
DOIs
StatePublished - Aug 1987

Keywords

  • Calcium uptake
  • Cardiomyopathy
  • Noradrenaline
  • Sarcoplasmic reticulum

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