Calcium antagonists, is there a real concern about safety?

D. A. Duprez, M. L. De Buyzere, D. L. Clement

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Calcium antagonists are widely used in the treatment of arterial hypertension and, or in ischemic heart disease. During the last 3 years, controversial articles and editorials have been published concerning the potential risk of calcium antagonists in regard to mortality, cancer and haemorrhage. The information has been mainly derived from case-control studies. The major concern about such observational studies of treatment outcome is the large potential for systematic error to affect the results. However, overviews of controlled trials with calcium antagonists do not provide clear evidence of an effect of calcium antagonists on mortality, risk of cancer and risk of bleeding.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalActa clinica Belgica
Issue number2
StatePublished - Jun 25 1998


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