Calcitonin: chronotherapeutic effect on osteopenia in the ovariectomized rat.

D. J. Simmons, C. Yang, C. M. Gundberg, L. Kidder, G. Cornelissen, M. Thomas, R. Lozano, E. Sandstead

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


This chronotherapeutic study has revealed no clear evidence to support the concept that calcitonin promotes bone formation in intact or OVX'd rats. Rather, the efficacy of CT-impaired bone resorption appeared to be optimal in OVX'd rats treated during the daytime, and least effective during the first half of the environmental dark span. These findings indicate a benefit for calcitonin chronotherapy in this animal model where the cellular kinetics resemble those documented in early development of postmenopausal osteoporosis.

Original languageEnglish (US)
Pages (from-to)517-527
Number of pages11
JournalProgress in clinical and biological research
Volume341 A
StatePublished - 1990


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