Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: Correlation with outcome in solid organ transplant recipients with cryptococcosis

Dimitrios P. Kontoyiannis; Russell E. Lewis; Barbara D. Alexander; Olivier Lortholary; Françoise Dromer; Krishan L. Gupta; George T. John; Ramon Del Busto; Goran B. Klintmalm; Jyoti Somani; G. Marshall Lyon; Kenneth Pursell; Valentina Stosor; Patricia Muňoz; Ajit P. Limaye; Andre C. Kalil; Timothy L. Pruett; Julia Garcia-Diaz; Atul Humar; Sally Houston; Andrew A. House; Dannah Wray; Susan Orloff; Lorraine A. Dowdy; Robert A. Fisher; Joseph Heitman; Nathaniel D. Albert; Marilyn M. Wagener; Nina Singh

doi:10.1128/AAC.00990-07

Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: Correlation with outcome in solid organ transplant recipients with cryptococcosis

Dimitrios P. Kontoyiannis
, Russell E. Lewis
, Barbara D. Alexander
, Olivier Lortholary
, Françoise Dromer
, Krishan L. Gupta
, George T. John
, Ramon Del Busto
, Goran B. Klintmalm
, Jyoti Somani
, G. Marshall Lyon
, Kenneth Pursell
, Valentina Stosor
, Patricia Muňoz
, Ajit P. Limaye
, Andre C. Kalil
, Timothy L. Pruett
, Julia Garcia-Diaz
, Atul Humar
, Sally Houston

Andrew A. House, Dannah Wray, Susan Orloff, Lorraine A. Dowdy, Robert A. Fisher, Joseph Heitman, Nathaniel D. Albert, Marilyn M. Wagener, Nina Singh

Surgery

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.

Original language	English (US)
Pages (from-to)	735-738
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	52
Issue number	2
DOIs	https://doi.org/10.1128/AAC.00990-07
State	Published - Feb 2008

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Kontoyiannis, D. P., Lewis, R. E., Alexander, B. D., Lortholary, O., Dromer, F., Gupta, K. L., John, G. T., Del Busto, R., Klintmalm, G. B., Somani, J., Lyon, G. M., Pursell, K., Stosor, V., Muňoz, P., Limaye, A. P., Kalil, A. C., Pruett, T. L., Garcia-Diaz, J., Humar, A., ... Singh, N. (2008). Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: Correlation with outcome in solid organ transplant recipients with cryptococcosis. Antimicrobial agents and chemotherapy, 52(2), 735-738. https://doi.org/10.1128/AAC.00990-07

Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: Correlation with outcome in solid organ transplant recipients with cryptococcosis. / Kontoyiannis, Dimitrios P.; Lewis, Russell E.; Alexander, Barbara D. et al.
In: Antimicrobial agents and chemotherapy, Vol. 52, No. 2, 02.2008, p. 735-738.

Research output: Contribution to journal › Article › peer-review

Kontoyiannis, DP, Lewis, RE, Alexander, BD, Lortholary, O, Dromer, F, Gupta, KL, John, GT, Del Busto, R, Klintmalm, GB, Somani, J, Lyon, GM, Pursell, K, Stosor, V, Muňoz, P, Limaye, AP, Kalil, AC, Pruett, TL, Garcia-Diaz, J, Humar, A, Houston, S, House, AA, Wray, D, Orloff, S, Dowdy, LA, Fisher, RA, Heitman, J, Albert, ND, Wagener, MM & Singh, N 2008, 'Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: Correlation with outcome in solid organ transplant recipients with cryptococcosis', Antimicrobial agents and chemotherapy, vol. 52, no. 2, pp. 735-738. https://doi.org/10.1128/AAC.00990-07

Kontoyiannis DP, Lewis RE, Alexander BD, Lortholary O, Dromer F, Gupta KL et al. Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: Correlation with outcome in solid organ transplant recipients with cryptococcosis. Antimicrobial agents and chemotherapy. 2008 Feb;52(2):735-738. doi: 10.1128/AAC.00990-07

Kontoyiannis, Dimitrios P. ; Lewis, Russell E. ; Alexander, Barbara D. et al. / Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates : Correlation with outcome in solid organ transplant recipients with cryptococcosis. In: Antimicrobial agents and chemotherapy. 2008 ; Vol. 52, No. 2. pp. 735-738.

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title = "Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: Correlation with outcome in solid organ transplant recipients with cryptococcosis",

abstract = "Synergistic interactions were observed between CIs and antifungal agents against 53 (90\%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.",

author = "Kontoyiannis, \{Dimitrios P.\} and Lewis, \{Russell E.\} and Alexander, \{Barbara D.\} and Olivier Lortholary and Fran{\c c}oise Dromer and Gupta, \{Krishan L.\} and John, \{George T.\} and \{Del Busto\}, Ramon and Klintmalm, \{Goran B.\} and Jyoti Somani and Lyon, \{G. Marshall\} and Kenneth Pursell and Valentina Stosor and Patricia Mu{\v n}oz and Limaye, \{Ajit P.\} and Kalil, \{Andre C.\} and Pruett, \{Timothy L.\} and Julia Garcia-Diaz and Atul Humar and Sally Houston and House, \{Andrew A.\} and Dannah Wray and Susan Orloff and Dowdy, \{Lorraine A.\} and Fisher, \{Robert A.\} and Joseph Heitman and Albert, \{Nathaniel D.\} and Wagener, \{Marilyn M.\} and Nina Singh",

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AU - Alexander, Barbara D.

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AU - Somani, Jyoti

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AU - Muňoz, Patricia

AU - Limaye, Ajit P.

AU - Kalil, Andre C.

AU - Pruett, Timothy L.

AU - Garcia-Diaz, Julia

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AU - Houston, Sally

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AU - Wray, Dannah

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Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: Correlation with outcome in solid organ transplant recipients with cryptococcosis

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