Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus

William J. Steinbach; Robert A. Cramer; B. Zachary Perfect; Christina Henn; Kirsten Nielsen; Joseph Heitman; John R. Perfect

doi:10.1128/AAC.01394-06

Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus

William J. Steinbach
, Robert A. Cramer
, B. Zachary Perfect
, Christina Henn
, Kirsten Nielsen
, Joseph Heitman
, John R. Perfect

Microbiology

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-β-D-glucan revealed decreased amounts in the calcineurin A (ΔcnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.

Original language	English (US)
Pages (from-to)	2979-2981
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	51
Issue number	8
DOIs	https://doi.org/10.1128/AAC.01394-06
State	Published - Aug 2007

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10.1128/AAC.01394-06

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title = "Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus",

abstract = "Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-β-D-glucan revealed decreased amounts in the calcineurin A (ΔcnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.",

author = "Steinbach, \{William J.\} and Cramer, \{Robert A.\} and Perfect, \{B. Zachary\} and Christina Henn and Kirsten Nielsen and Joseph Heitman and Perfect, \{John R.\}",

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AU - Steinbach, William J.

AU - Cramer, Robert A.

AU - Perfect, B. Zachary

AU - Henn, Christina

AU - Nielsen, Kirsten

AU - Heitman, Joseph

AU - Perfect, John R.

PY - 2007/8

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N2 - Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-β-D-glucan revealed decreased amounts in the calcineurin A (ΔcnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.

AB - Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-β-D-glucan revealed decreased amounts in the calcineurin A (ΔcnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.

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JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 8

ER -

Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus

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