Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus

William J. Steinbach, Robert A. Cramer, B. Zachary Perfect, Christina Henn, Kirsten Nielsen, Joseph Heitman, John R. Perfect

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-β-D-glucan revealed decreased amounts in the calcineurin A (ΔcnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.

Original languageEnglish (US)
Pages (from-to)2979-2981
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number8
DOIs
StatePublished - Aug 2007

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