Abstract
Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-β-D-glucan revealed decreased amounts in the calcineurin A (ΔcnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.
Original language | English (US) |
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Pages (from-to) | 2979-2981 |
Number of pages | 3 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 51 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2007 |