Ca(II)-Catalyzed Regioselective Cascade Synthesis of Oxindolyl- Naphthofurans through Meyer-Schuster type Rearrangement

Srinivasarao Yaragorla, Ravikrishna Dada, Garima Singh, Abhishek Pareek, Monika Rana, Anuj K. Sharma

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Highly regioselective synthesis of 3-Oxindolyl naphthofurans has been described through an interesting Meyer-Schuster (M−S) type rearrangement followed by oxacyclisation using environmentally benign calcium salt. This synthetic protocol is ornamented with many of the green synthetic aspects such as solvent free, one pot cascade, -atom economy, step economy and the use of calcium salt which is highly abundant in the nature. The selected compounds were tested for their preliminary anti-amyloidogenic properties to highlight the importance of such compounds and methodologies.

Original languageEnglish (US)
Pages (from-to)6902-6906
Number of pages5
JournalChemistrySelect
Volume1
Issue number21
DOIs
StatePublished - Dec 16 2016
Externally publishedYes

Bibliographical note

Funding Information:
SY thank DST (SERB) for the research grant under Fast track Young Scientist scheme (SB/FT/CS-149/2012). RD, GS, AP and MR thank Central University of Rajasthan for the fellowship. AKS thank DST-INSPIRE programme for research grant IFA-13, CH-97. Dr. Gopal K is acknowledged for the technical support.

Publisher Copyright:
© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • Calcium Catalysis
  • Green Chemistry
  • Meyer-Schuster type rearrangement
  • Oxindoles, Naphthofurans
  • Regioselective

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