Highly regioselective synthesis of 3-Oxindolyl naphthofurans has been described through an interesting Meyer-Schuster (M−S) type rearrangement followed by oxacyclisation using environmentally benign calcium salt. This synthetic protocol is ornamented with many of the green synthetic aspects such as solvent free, one pot cascade, -atom economy, step economy and the use of calcium salt which is highly abundant in the nature. The selected compounds were tested for their preliminary anti-amyloidogenic properties to highlight the importance of such compounds and methodologies.
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- Calcium Catalysis
- Green Chemistry
- Meyer-Schuster type rearrangement
- Oxindoles, Naphthofurans