Caffeine, extended stress, and blood pressure in borderline hypertensive men

William R. Lovallo, Mustafa al’Absi, Gwen A. Pincomb, Richard B. Passey, Bong Hee Sung, Michael F. Wilson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Caffeine increases blood pressure (BP), and its pressor effects are larger in borderline hypertensive (BH) men than in controls. This article extends findings of larger caffeine effects on BP at rest and to brief mental stress in BH to a new analysis of caffeine and prolonged mental stress in BH. In a double-blind, crossover study, 24 male BH (140/90 mmHg < BP < 160/95 mmHg) and 23 normotensive controls who were habitual caffeine consumers (NT; BP < 135/85 mmHg; negative parental history) worked on alternating mental stressors for 35 min after placebo or caffeine (3.3 mg/kg). Caffeine raised systolic blood pressure (SBP) and diastolic blood pressure (DBP) alone and during the extended tasks (all ps < .00001/.00001). BH had larger SBP and DBP increases over all postcaffeine periods (ps < .04/04) and larger DBP rises to the extended tasks after caffeine (p = .007). These combined effects led to undesirably high BPs (> 140/82 mmHg) relative to controls (< 130/75) during the 100 min after caffeine intake. Caffeine taken by BH at times of extended behavioral stress may elevate BP to a clinically meaningful degree.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalInternational Journal of Behavioral Medicine
Issue number2
StatePublished - 2000

Bibliographical note

Funding Information:
This research was supported by the Medical Research Service of the Department of Veterans Affairs and the National Heart Lung and Blood Institute of the National Institutes of Health, grant numbers HL32050 and HL07640.


  • Blood pressure
  • Caffeine
  • Hypertension
  • Stress


Dive into the research topics of 'Caffeine, extended stress, and blood pressure in borderline hypertensive men'. Together they form a unique fingerprint.

Cite this