Cadmium, obesity, and education, and the 10-year incidence of hearing impairment

The beaver dam offspring study

Dayna S. Dalton, Carla R. Schubert, Alex Pinto, Mary E. Fischer, Guan Hua Huang, Barbara E.K. Klein, Ronald Klein, Jim Pankow, Adam J. Paulsen, Michael Y Tsai, Ted S. Tweed, Karen J. Cruickshanks

Research output: Contribution to journalArticle

Abstract

Objectives/Hypothesis: To determine the 10-year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004–present), a large middle-aged cohort followed for 10 years. Study Design: Prospective cohort study. Methods: Hearing thresholds were measured at baseline (2005–2008) and 5- (2010–2013) and 10-year (2015–2017) follow-up examinations. HI was defined as a pure-tone average >25 dB HL in either ear. BOSS participants free of HI at baseline with at least one follow-up examination (N = 2,065) were included. Potential risk factors evaluated included cardiovascular measures, health history, lifestyle factors, inflammatory markers, vitamins D and B12, lead, and cadmium. Results: Participants were 21 to 79 years (mean age = 47.9 years) at baseline. The 10-year cumulative HI incidence was 17.4% (95% confidence interval [CI]: 15.7–19.2) and was twice as likely in men (24.4%, 95% CI: 21.5–27.7) than in women (12.2%, 95% CI: 10.3–14.3). In a multivariable adjusted model, age (hazard ratio [HR] = 1.48, 95% CI: 1.38–1.59, per 5 years), male sex (HR = 2.47, 95% CI: 1.91–3.18), less than a college education (HR = 1.35, 95% CI: 1.02–1.79), body mass index (HR = 1.03, 95% CI: 1.01–1.05, per kg/m2), and higher cadmium levels (HR = 1.42, 95% CI: 1.05–1.92, quintile 5 vs. quintiles 1–4) were associated with the 10-year cumulative incidence of HI. There was no association between high lead levels, vitamins D or B12, and 10-year incidence of HI. Conclusions: In addition to age and sex, obesity, education, and blood cadmium levels were associated with increased incidence of HI. These prospective results add to evidence that age-related HI is a multifactorial preventable disorder. Level of Evidence: 2b Laryngoscope, 2019.

Original languageEnglish (US)
JournalLaryngoscope
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Cadmium
Hearing Loss
Rodentia
Obesity
Confidence Intervals
Education
Incidence
Vitamin B 12
Vitamin D
Laryngoscopes
Sex Education
Sex Ratio
Proportional Hazards Models
Hearing
Ear
Life Style
Body Mass Index
Cohort Studies
Prospective Studies
Health

Keywords

  • epidemiology
  • midlife
  • neurotoxins
  • risk factors
  • Sensorineural hearing loss

PubMed: MeSH publication types

  • Journal Article

Cite this

Dalton, D. S., Schubert, C. R., Pinto, A., Fischer, M. E., Huang, G. H., Klein, B. E. K., ... Cruickshanks, K. J. (Accepted/In press). Cadmium, obesity, and education, and the 10-year incidence of hearing impairment: The beaver dam offspring study. Laryngoscope. https://doi.org/10.1002/lary.28244

Cadmium, obesity, and education, and the 10-year incidence of hearing impairment : The beaver dam offspring study. / Dalton, Dayna S.; Schubert, Carla R.; Pinto, Alex; Fischer, Mary E.; Huang, Guan Hua; Klein, Barbara E.K.; Klein, Ronald; Pankow, Jim; Paulsen, Adam J.; Tsai, Michael Y; Tweed, Ted S.; Cruickshanks, Karen J.

In: Laryngoscope, 01.01.2019.

Research output: Contribution to journalArticle

Dalton, DS, Schubert, CR, Pinto, A, Fischer, ME, Huang, GH, Klein, BEK, Klein, R, Pankow, J, Paulsen, AJ, Tsai, MY, Tweed, TS & Cruickshanks, KJ 2019, 'Cadmium, obesity, and education, and the 10-year incidence of hearing impairment: The beaver dam offspring study', Laryngoscope. https://doi.org/10.1002/lary.28244
Dalton, Dayna S. ; Schubert, Carla R. ; Pinto, Alex ; Fischer, Mary E. ; Huang, Guan Hua ; Klein, Barbara E.K. ; Klein, Ronald ; Pankow, Jim ; Paulsen, Adam J. ; Tsai, Michael Y ; Tweed, Ted S. ; Cruickshanks, Karen J. / Cadmium, obesity, and education, and the 10-year incidence of hearing impairment : The beaver dam offspring study. In: Laryngoscope. 2019.
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abstract = "Objectives/Hypothesis: To determine the 10-year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004–present), a large middle-aged cohort followed for 10 years. Study Design: Prospective cohort study. Methods: Hearing thresholds were measured at baseline (2005–2008) and 5- (2010–2013) and 10-year (2015–2017) follow-up examinations. HI was defined as a pure-tone average >25 dB HL in either ear. BOSS participants free of HI at baseline with at least one follow-up examination (N = 2,065) were included. Potential risk factors evaluated included cardiovascular measures, health history, lifestyle factors, inflammatory markers, vitamins D and B12, lead, and cadmium. Results: Participants were 21 to 79 years (mean age = 47.9 years) at baseline. The 10-year cumulative HI incidence was 17.4{\%} (95{\%} confidence interval [CI]: 15.7–19.2) and was twice as likely in men (24.4{\%}, 95{\%} CI: 21.5–27.7) than in women (12.2{\%}, 95{\%} CI: 10.3–14.3). In a multivariable adjusted model, age (hazard ratio [HR] = 1.48, 95{\%} CI: 1.38–1.59, per 5 years), male sex (HR = 2.47, 95{\%} CI: 1.91–3.18), less than a college education (HR = 1.35, 95{\%} CI: 1.02–1.79), body mass index (HR = 1.03, 95{\%} CI: 1.01–1.05, per kg/m2), and higher cadmium levels (HR = 1.42, 95{\%} CI: 1.05–1.92, quintile 5 vs. quintiles 1–4) were associated with the 10-year cumulative incidence of HI. There was no association between high lead levels, vitamins D or B12, and 10-year incidence of HI. Conclusions: In addition to age and sex, obesity, education, and blood cadmium levels were associated with increased incidence of HI. These prospective results add to evidence that age-related HI is a multifactorial preventable disorder. Level of Evidence: 2b Laryngoscope, 2019.",
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T1 - Cadmium, obesity, and education, and the 10-year incidence of hearing impairment

T2 - The beaver dam offspring study

AU - Dalton, Dayna S.

AU - Schubert, Carla R.

AU - Pinto, Alex

AU - Fischer, Mary E.

AU - Huang, Guan Hua

AU - Klein, Barbara E.K.

AU - Klein, Ronald

AU - Pankow, Jim

AU - Paulsen, Adam J.

AU - Tsai, Michael Y

AU - Tweed, Ted S.

AU - Cruickshanks, Karen J.

PY - 2019/1/1

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N2 - Objectives/Hypothesis: To determine the 10-year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004–present), a large middle-aged cohort followed for 10 years. Study Design: Prospective cohort study. Methods: Hearing thresholds were measured at baseline (2005–2008) and 5- (2010–2013) and 10-year (2015–2017) follow-up examinations. HI was defined as a pure-tone average >25 dB HL in either ear. BOSS participants free of HI at baseline with at least one follow-up examination (N = 2,065) were included. Potential risk factors evaluated included cardiovascular measures, health history, lifestyle factors, inflammatory markers, vitamins D and B12, lead, and cadmium. Results: Participants were 21 to 79 years (mean age = 47.9 years) at baseline. The 10-year cumulative HI incidence was 17.4% (95% confidence interval [CI]: 15.7–19.2) and was twice as likely in men (24.4%, 95% CI: 21.5–27.7) than in women (12.2%, 95% CI: 10.3–14.3). In a multivariable adjusted model, age (hazard ratio [HR] = 1.48, 95% CI: 1.38–1.59, per 5 years), male sex (HR = 2.47, 95% CI: 1.91–3.18), less than a college education (HR = 1.35, 95% CI: 1.02–1.79), body mass index (HR = 1.03, 95% CI: 1.01–1.05, per kg/m2), and higher cadmium levels (HR = 1.42, 95% CI: 1.05–1.92, quintile 5 vs. quintiles 1–4) were associated with the 10-year cumulative incidence of HI. There was no association between high lead levels, vitamins D or B12, and 10-year incidence of HI. Conclusions: In addition to age and sex, obesity, education, and blood cadmium levels were associated with increased incidence of HI. These prospective results add to evidence that age-related HI is a multifactorial preventable disorder. Level of Evidence: 2b Laryngoscope, 2019.

AB - Objectives/Hypothesis: To determine the 10-year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004–present), a large middle-aged cohort followed for 10 years. Study Design: Prospective cohort study. Methods: Hearing thresholds were measured at baseline (2005–2008) and 5- (2010–2013) and 10-year (2015–2017) follow-up examinations. HI was defined as a pure-tone average >25 dB HL in either ear. BOSS participants free of HI at baseline with at least one follow-up examination (N = 2,065) were included. Potential risk factors evaluated included cardiovascular measures, health history, lifestyle factors, inflammatory markers, vitamins D and B12, lead, and cadmium. Results: Participants were 21 to 79 years (mean age = 47.9 years) at baseline. The 10-year cumulative HI incidence was 17.4% (95% confidence interval [CI]: 15.7–19.2) and was twice as likely in men (24.4%, 95% CI: 21.5–27.7) than in women (12.2%, 95% CI: 10.3–14.3). In a multivariable adjusted model, age (hazard ratio [HR] = 1.48, 95% CI: 1.38–1.59, per 5 years), male sex (HR = 2.47, 95% CI: 1.91–3.18), less than a college education (HR = 1.35, 95% CI: 1.02–1.79), body mass index (HR = 1.03, 95% CI: 1.01–1.05, per kg/m2), and higher cadmium levels (HR = 1.42, 95% CI: 1.05–1.92, quintile 5 vs. quintiles 1–4) were associated with the 10-year cumulative incidence of HI. There was no association between high lead levels, vitamins D or B12, and 10-year incidence of HI. Conclusions: In addition to age and sex, obesity, education, and blood cadmium levels were associated with increased incidence of HI. These prospective results add to evidence that age-related HI is a multifactorial preventable disorder. Level of Evidence: 2b Laryngoscope, 2019.

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KW - midlife

KW - neurotoxins

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KW - Sensorineural hearing loss

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