Cadmium, obesity, and education, and the 10-year incidence of hearing impairment: The beaver dam offspring study

Dayna S. Dalton, Carla R. Schubert, Alex Pinto, Mary E. Fischer, Guan Hua Huang, Barbara E.K. Klein, Ronald Klein, Jim Pankow, Adam J. Paulsen, Michael Y Tsai, Ted S. Tweed, Karen J. Cruickshanks

Research output: Contribution to journalArticle

Abstract

Objectives/Hypothesis: To determine the 10-year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004–present), a large middle-aged cohort followed for 10 years. Study Design: Prospective cohort study. Methods: Hearing thresholds were measured at baseline (2005–2008) and 5- (2010–2013) and 10-year (2015–2017) follow-up examinations. HI was defined as a pure-tone average >25 dB HL in either ear. BOSS participants free of HI at baseline with at least one follow-up examination (N = 2,065) were included. Potential risk factors evaluated included cardiovascular measures, health history, lifestyle factors, inflammatory markers, vitamins D and B12, lead, and cadmium. Results: Participants were 21 to 79 years (mean age = 47.9 years) at baseline. The 10-year cumulative HI incidence was 17.4% (95% confidence interval [CI]: 15.7–19.2) and was twice as likely in men (24.4%, 95% CI: 21.5–27.7) than in women (12.2%, 95% CI: 10.3–14.3). In a multivariable adjusted model, age (hazard ratio [HR] = 1.48, 95% CI: 1.38–1.59, per 5 years), male sex (HR = 2.47, 95% CI: 1.91–3.18), less than a college education (HR = 1.35, 95% CI: 1.02–1.79), body mass index (HR = 1.03, 95% CI: 1.01–1.05, per kg/m2), and higher cadmium levels (HR = 1.42, 95% CI: 1.05–1.92, quintile 5 vs. quintiles 1–4) were associated with the 10-year cumulative incidence of HI. There was no association between high lead levels, vitamins D or B12, and 10-year incidence of HI. Conclusions: In addition to age and sex, obesity, education, and blood cadmium levels were associated with increased incidence of HI. These prospective results add to evidence that age-related HI is a multifactorial preventable disorder. Level of Evidence: 2b Laryngoscope, 2019.

Original languageEnglish (US)
JournalLaryngoscope
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Cadmium
Hearing Loss
Rodentia
Obesity
Confidence Intervals
Education
Incidence
Vitamin B 12
Vitamin D
Laryngoscopes
Sex Education
Sex Ratio
Proportional Hazards Models
Hearing
Ear
Life Style
Body Mass Index
Cohort Studies
Prospective Studies
Health

Keywords

  • Sensorineural hearing loss
  • epidemiology
  • midlife
  • neurotoxins
  • risk factors

PubMed: MeSH publication types

  • Journal Article

Cite this

Dalton, D. S., Schubert, C. R., Pinto, A., Fischer, M. E., Huang, G. H., Klein, B. E. K., ... Cruickshanks, K. J. (Accepted/In press). Cadmium, obesity, and education, and the 10-year incidence of hearing impairment: The beaver dam offspring study. Laryngoscope. https://doi.org/10.1002/lary.28244

Cadmium, obesity, and education, and the 10-year incidence of hearing impairment : The beaver dam offspring study. / Dalton, Dayna S.; Schubert, Carla R.; Pinto, Alex; Fischer, Mary E.; Huang, Guan Hua; Klein, Barbara E.K.; Klein, Ronald; Pankow, Jim; Paulsen, Adam J.; Tsai, Michael Y; Tweed, Ted S.; Cruickshanks, Karen J.

In: Laryngoscope, 01.01.2019.

Research output: Contribution to journalArticle

Dalton, DS, Schubert, CR, Pinto, A, Fischer, ME, Huang, GH, Klein, BEK, Klein, R, Pankow, J, Paulsen, AJ, Tsai, MY, Tweed, TS & Cruickshanks, KJ 2019, 'Cadmium, obesity, and education, and the 10-year incidence of hearing impairment: The beaver dam offspring study', Laryngoscope. https://doi.org/10.1002/lary.28244
Dalton, Dayna S. ; Schubert, Carla R. ; Pinto, Alex ; Fischer, Mary E. ; Huang, Guan Hua ; Klein, Barbara E.K. ; Klein, Ronald ; Pankow, Jim ; Paulsen, Adam J. ; Tsai, Michael Y ; Tweed, Ted S. ; Cruickshanks, Karen J. / Cadmium, obesity, and education, and the 10-year incidence of hearing impairment : The beaver dam offspring study. In: Laryngoscope. 2019.
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abstract = "Objectives/Hypothesis: To determine the 10-year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004–present), a large middle-aged cohort followed for 10 years. Study Design: Prospective cohort study. Methods: Hearing thresholds were measured at baseline (2005–2008) and 5- (2010–2013) and 10-year (2015–2017) follow-up examinations. HI was defined as a pure-tone average >25 dB HL in either ear. BOSS participants free of HI at baseline with at least one follow-up examination (N = 2,065) were included. Potential risk factors evaluated included cardiovascular measures, health history, lifestyle factors, inflammatory markers, vitamins D and B12, lead, and cadmium. Results: Participants were 21 to 79 years (mean age = 47.9 years) at baseline. The 10-year cumulative HI incidence was 17.4{\%} (95{\%} confidence interval [CI]: 15.7–19.2) and was twice as likely in men (24.4{\%}, 95{\%} CI: 21.5–27.7) than in women (12.2{\%}, 95{\%} CI: 10.3–14.3). In a multivariable adjusted model, age (hazard ratio [HR] = 1.48, 95{\%} CI: 1.38–1.59, per 5 years), male sex (HR = 2.47, 95{\%} CI: 1.91–3.18), less than a college education (HR = 1.35, 95{\%} CI: 1.02–1.79), body mass index (HR = 1.03, 95{\%} CI: 1.01–1.05, per kg/m2), and higher cadmium levels (HR = 1.42, 95{\%} CI: 1.05–1.92, quintile 5 vs. quintiles 1–4) were associated with the 10-year cumulative incidence of HI. There was no association between high lead levels, vitamins D or B12, and 10-year incidence of HI. Conclusions: In addition to age and sex, obesity, education, and blood cadmium levels were associated with increased incidence of HI. These prospective results add to evidence that age-related HI is a multifactorial preventable disorder. Level of Evidence: 2b Laryngoscope, 2019.",
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T1 - Cadmium, obesity, and education, and the 10-year incidence of hearing impairment

T2 - The beaver dam offspring study

AU - Dalton, Dayna S.

AU - Schubert, Carla R.

AU - Pinto, Alex

AU - Fischer, Mary E.

AU - Huang, Guan Hua

AU - Klein, Barbara E.K.

AU - Klein, Ronald

AU - Pankow, Jim

AU - Paulsen, Adam J.

AU - Tsai, Michael Y

AU - Tweed, Ted S.

AU - Cruickshanks, Karen J.

PY - 2019/1/1

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N2 - Objectives/Hypothesis: To determine the 10-year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004–present), a large middle-aged cohort followed for 10 years. Study Design: Prospective cohort study. Methods: Hearing thresholds were measured at baseline (2005–2008) and 5- (2010–2013) and 10-year (2015–2017) follow-up examinations. HI was defined as a pure-tone average >25 dB HL in either ear. BOSS participants free of HI at baseline with at least one follow-up examination (N = 2,065) were included. Potential risk factors evaluated included cardiovascular measures, health history, lifestyle factors, inflammatory markers, vitamins D and B12, lead, and cadmium. Results: Participants were 21 to 79 years (mean age = 47.9 years) at baseline. The 10-year cumulative HI incidence was 17.4% (95% confidence interval [CI]: 15.7–19.2) and was twice as likely in men (24.4%, 95% CI: 21.5–27.7) than in women (12.2%, 95% CI: 10.3–14.3). In a multivariable adjusted model, age (hazard ratio [HR] = 1.48, 95% CI: 1.38–1.59, per 5 years), male sex (HR = 2.47, 95% CI: 1.91–3.18), less than a college education (HR = 1.35, 95% CI: 1.02–1.79), body mass index (HR = 1.03, 95% CI: 1.01–1.05, per kg/m2), and higher cadmium levels (HR = 1.42, 95% CI: 1.05–1.92, quintile 5 vs. quintiles 1–4) were associated with the 10-year cumulative incidence of HI. There was no association between high lead levels, vitamins D or B12, and 10-year incidence of HI. Conclusions: In addition to age and sex, obesity, education, and blood cadmium levels were associated with increased incidence of HI. These prospective results add to evidence that age-related HI is a multifactorial preventable disorder. Level of Evidence: 2b Laryngoscope, 2019.

AB - Objectives/Hypothesis: To determine the 10-year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004–present), a large middle-aged cohort followed for 10 years. Study Design: Prospective cohort study. Methods: Hearing thresholds were measured at baseline (2005–2008) and 5- (2010–2013) and 10-year (2015–2017) follow-up examinations. HI was defined as a pure-tone average >25 dB HL in either ear. BOSS participants free of HI at baseline with at least one follow-up examination (N = 2,065) were included. Potential risk factors evaluated included cardiovascular measures, health history, lifestyle factors, inflammatory markers, vitamins D and B12, lead, and cadmium. Results: Participants were 21 to 79 years (mean age = 47.9 years) at baseline. The 10-year cumulative HI incidence was 17.4% (95% confidence interval [CI]: 15.7–19.2) and was twice as likely in men (24.4%, 95% CI: 21.5–27.7) than in women (12.2%, 95% CI: 10.3–14.3). In a multivariable adjusted model, age (hazard ratio [HR] = 1.48, 95% CI: 1.38–1.59, per 5 years), male sex (HR = 2.47, 95% CI: 1.91–3.18), less than a college education (HR = 1.35, 95% CI: 1.02–1.79), body mass index (HR = 1.03, 95% CI: 1.01–1.05, per kg/m2), and higher cadmium levels (HR = 1.42, 95% CI: 1.05–1.92, quintile 5 vs. quintiles 1–4) were associated with the 10-year cumulative incidence of HI. There was no association between high lead levels, vitamins D or B12, and 10-year incidence of HI. Conclusions: In addition to age and sex, obesity, education, and blood cadmium levels were associated with increased incidence of HI. These prospective results add to evidence that age-related HI is a multifactorial preventable disorder. Level of Evidence: 2b Laryngoscope, 2019.

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KW - midlife

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