(C3) The oral epithelial cell and first encounters with HIV-1.

Mark C Herzberg, A. Weinberg, S. M. Wahl

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The oral epithelium is the site of first exposure of HIV-1 to host tissues during oral sex with an infected partner or through breast-feeding by an infected mother. Although the oral epithelium is distinguishable by its apparent resistance, the mucosal surfaces represent a primary target of HIV-1. After oral exposure and swallowing, infection is detected prominently in the gastrointestinal tract, which becomes depleted of CD4+ T-cells. The oral cavity and palatine tonsils appear to resist infection and transfer to susceptible lymphoid cells in the lamina propria by local anti-HIV-1 mechanisms. In some cases, expression of these antiviral mechanisms increases after exposure to HIV-1. During primary exposure and before seroconversion, based on limited in vitro and primate data, a window of opportunity for capture of HIV-1 by the oral epithelium may exist. After seroconversion, the risk of infectious HIV-1 appearing in saliva is negligible. This report considers evidence that oral epithelium has the potential both to enable and to resist infection by HIV-1.

Original languageEnglish (US)
Pages (from-to)158-166
Number of pages9
JournalAdvances in dental research
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2006

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HIV-1
Epithelial Cells
Epithelium
Infection
Palatine Tonsil
Deglutition
Breast Feeding
Saliva
Sexual Behavior
Primates
Antiviral Agents
Mouth
Gastrointestinal Tract
Mucous Membrane
Lymphocytes
T-Lymphocytes

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(C3) The oral epithelial cell and first encounters with HIV-1. / Herzberg, Mark C; Weinberg, A.; Wahl, S. M.

In: Advances in dental research, Vol. 19, No. 1, 01.01.2006, p. 158-166.

Research output: Contribution to journalArticle

Herzberg, Mark C ; Weinberg, A. ; Wahl, S. M. / (C3) The oral epithelial cell and first encounters with HIV-1. In: Advances in dental research. 2006 ; Vol. 19, No. 1. pp. 158-166.
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