C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery

Tjörvi E. Perry, Jochen D. Muehlschlegel, Kuang Yu Liu, Amanda A. Fox, Charles D. Collard, Simon C. Body, Stanton K. Shernan

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background: Elevated baseline C-reactive protein (CRP) levels are associated with increased risk for developing cardiovascular disease. Several CRP gene variants have been associated with altered baseline CRP levels in ambulatory populations. However, the influence of CRP gene variants on CRP levels during inflammatory states, such as surgery, is largely unexplored. We describe the association between candidate CRP gene variants and postoperative plasma CRP levels in patients undergoing primary, elective coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB). Methods: Using a multicenter candidate gene association study design, we examined the association between seventeen candidate CRP single nucleotide polymorphisms (SNPs) and inferred haplotypes, and altered postoperative CRP levels in 604 patients undergoing CABG surgery with CPB. Perioperative CRP levels were measured immediately prior to surgery, post-CPB and on postoperative days (POD) 1-4. Results: CRP levels were significantly elevated at all postoperative time points when compared with preoperative levels (P < 0.0001). After adjusting for clinical covariates, the minor allele of the synonymous coding SNP, rs1800947 was associated with lower peak postoperative CRP levels (P = 2.4 × 10-4) and lower CRP levels across all postoperative time points (P = 4.8 × 10-5). rs1800947 remained highly significant after Bonferroni adjustment for multiple comparisons. Conclusion: We identified a CRP gene SNP associated with lower postoperative CRP levels in patients undergoing CABG surgery with CPB. Further investigation is needed to clarify the significance of this association between CRP gene variants and the acute-phase rise in postoperative CRP levels with regard to the risk of adverse postoperative outcomes.

Original languageEnglish (US)
Article number38
JournalBMC medical genetics
StatePublished - May 8 2009

Bibliographical note

Funding Information:
TEP, JDM, KYL, AAF have no competing interests to disclose. CDC, SCB, SKS have received grant support from Biosite, Inc.


Dive into the research topics of 'C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery'. Together they form a unique fingerprint.

Cite this