Butorphanol increases food-reinforced operant responding in satiated rats

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In the present series of studies we examined the effect of butorphanol tartrate on food-reinforced operant responding in satiated rats. In the first experiment, 8.0 mg/kg butorphanol was administered subcutaneously, once per day for 4 days, to satiated rats responding under an fixed ratio 10 (FR 10) reinforcement schedule. In the second experiment, butorphanol (0, 0.3, 1.0, 3.0, 10.0 mg/kg) was administered to satiated rats responding under an FR 80 (first pellet) FR 3 (subsequent pellets) reinforcement schedule for 4 consecutive days. Repeated butorphanol administration increased total amount of food consumed over sessions in both experiments. Under the FR 80 schedule component, butorphanol initially increased latency to acquire the first pellet, an effect attenuated by repeated administration. Whereas vehicle administration was associated with consumption of relatively large quantities of food within the first 10 min of receiving the first pellet, butorphanol was associated with continued feeding as the session progressed. These data suggest that butorphanol-induced food intake is associated with maintenance rather than initiation of feeding.

Original languageEnglish (US)
Pages (from-to)843-847
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume49
Issue number4
DOIs
StatePublished - Dec 1994

Bibliographical note

Funding Information:
ACKNOWLEDGEMENTS This work was supported by the Department of Veterans Affairs, the National Institute of Drug Abuse DA03999, and the National Institutes of Health DK42698.

Keywords

  • Butorphanol
  • Feeding
  • Operant
  • Opiates
  • Reinforcement

Fingerprint

Dive into the research topics of 'Butorphanol increases food-reinforced operant responding in satiated rats'. Together they form a unique fingerprint.

Cite this