Buprenorphine increases intake of freely available and operant-contingent food in satiated rats

J. M. Rudski, D. Thomas, C. J. Billington, A. S. Levine

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Opiate administration increases short-term free feeding in satiated rats. The feeding effects of the mixed opioid receptor agonist/antagonist buprenorphine were examined in both free-feeding and operant chamber paradigms. Buprenorphine (0.1 and 0.3 mg/kg) produced significant increases in short-term free feeding (i.e., 4 h), an effect enhanced by repeated administration. Buprenorphine's effects on operant responding were examined in satiated rats using a fixed ratio (FR) 80 (initial pellet) FR 3 (subsequent pellets) reinforcement schedule. Buprenorphine (0.03-0.3 mg/kg) decreased latency to begin responding for food and increased total number of pellets consumed in a 1-h session. Increases in food intake relative to control were caused by continued responding for food as sessions progressed. Naloxone suppressed both the free-feeding and operant-contingent intake induced by buprenorphine. Thus, buprenorphine increases both freely available and lever-press contingent food intake.

Original languageEnglish (US)
Pages (from-to)271-276
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume50
Issue number2
DOIs
StatePublished - Feb 1995

Keywords

  • Buprenorphine
  • Feeding
  • Operant
  • Opiates
  • Opioid
  • Reinforcement

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