Building a clinically relevant cognitive task: Case study of the AX paradigm

    Research output: Contribution to journalReview article

    44 Citations (Scopus)

    Abstract

    Tasks developed for basic cognitive neuroscience are often ill suited for experimental psychopathology. The development of the expectancy variant of AX continuous performance task to test theories about context processing in schizophrenia is used as an illustration of how this has been done in one research program. Four design principles are recommended: tasks should (1) have a foundation in existing literature and therefore stay as close as possible to an existing task; (2) be simple, which is frequently accomplished by paring down a task to evaluate the function of interest; (3) probe a mechanism of interest, with conditions that selectively manipulate this mechanism; and (4) have the potential to distinguish a specific deficit on the mechanism of interest from a generalized impairment. Data from a number of studies support several aspects of context-processing theory; however unpredicted results have also been reported. The development of the expectancy AX paradigm continues, and future developments that may enhance its usefulness are also described.

    Original languageEnglish (US)
    Pages (from-to)619-628
    Number of pages10
    JournalSchizophrenia bulletin
    Volume34
    Issue number4
    DOIs
    StatePublished - Jul 1 2008

    Fingerprint

    Task Performance and Analysis
    Psychopathology
    Schizophrenia
    Research
    Cognitive Neuroscience

    Keywords

    • Behavioral tasks
    • Context processing
    • Executive processes
    • Generalized deficit
    • Measurement
    • Schizophrenia
    • Testing
    • Translational research

    Cite this

    Building a clinically relevant cognitive task : Case study of the AX paradigm. / MacDonald, Angus W.

    In: Schizophrenia bulletin, Vol. 34, No. 4, 01.07.2008, p. 619-628.

    Research output: Contribution to journalReview article

    @article{18671f1badf34a7e875e0adb7dcd52c3,
    title = "Building a clinically relevant cognitive task: Case study of the AX paradigm",
    abstract = "Tasks developed for basic cognitive neuroscience are often ill suited for experimental psychopathology. The development of the expectancy variant of AX continuous performance task to test theories about context processing in schizophrenia is used as an illustration of how this has been done in one research program. Four design principles are recommended: tasks should (1) have a foundation in existing literature and therefore stay as close as possible to an existing task; (2) be simple, which is frequently accomplished by paring down a task to evaluate the function of interest; (3) probe a mechanism of interest, with conditions that selectively manipulate this mechanism; and (4) have the potential to distinguish a specific deficit on the mechanism of interest from a generalized impairment. Data from a number of studies support several aspects of context-processing theory; however unpredicted results have also been reported. The development of the expectancy AX paradigm continues, and future developments that may enhance its usefulness are also described.",
    keywords = "Behavioral tasks, Context processing, Executive processes, Generalized deficit, Measurement, Schizophrenia, Testing, Translational research",
    author = "MacDonald, {Angus W.}",
    year = "2008",
    month = "7",
    day = "1",
    doi = "10.1093/schbul/sbn038",
    language = "English (US)",
    volume = "34",
    pages = "619--628",
    journal = "Schizophrenia Bulletin",
    issn = "0586-7614",
    publisher = "Oxford University Press",
    number = "4",

    }

    TY - JOUR

    T1 - Building a clinically relevant cognitive task

    T2 - Case study of the AX paradigm

    AU - MacDonald, Angus W.

    PY - 2008/7/1

    Y1 - 2008/7/1

    N2 - Tasks developed for basic cognitive neuroscience are often ill suited for experimental psychopathology. The development of the expectancy variant of AX continuous performance task to test theories about context processing in schizophrenia is used as an illustration of how this has been done in one research program. Four design principles are recommended: tasks should (1) have a foundation in existing literature and therefore stay as close as possible to an existing task; (2) be simple, which is frequently accomplished by paring down a task to evaluate the function of interest; (3) probe a mechanism of interest, with conditions that selectively manipulate this mechanism; and (4) have the potential to distinguish a specific deficit on the mechanism of interest from a generalized impairment. Data from a number of studies support several aspects of context-processing theory; however unpredicted results have also been reported. The development of the expectancy AX paradigm continues, and future developments that may enhance its usefulness are also described.

    AB - Tasks developed for basic cognitive neuroscience are often ill suited for experimental psychopathology. The development of the expectancy variant of AX continuous performance task to test theories about context processing in schizophrenia is used as an illustration of how this has been done in one research program. Four design principles are recommended: tasks should (1) have a foundation in existing literature and therefore stay as close as possible to an existing task; (2) be simple, which is frequently accomplished by paring down a task to evaluate the function of interest; (3) probe a mechanism of interest, with conditions that selectively manipulate this mechanism; and (4) have the potential to distinguish a specific deficit on the mechanism of interest from a generalized impairment. Data from a number of studies support several aspects of context-processing theory; however unpredicted results have also been reported. The development of the expectancy AX paradigm continues, and future developments that may enhance its usefulness are also described.

    KW - Behavioral tasks

    KW - Context processing

    KW - Executive processes

    KW - Generalized deficit

    KW - Measurement

    KW - Schizophrenia

    KW - Testing

    KW - Translational research

    UR - http://www.scopus.com/inward/record.url?scp=46949107704&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=46949107704&partnerID=8YFLogxK

    U2 - 10.1093/schbul/sbn038

    DO - 10.1093/schbul/sbn038

    M3 - Review article

    C2 - 18487225

    AN - SCOPUS:46949107704

    VL - 34

    SP - 619

    EP - 628

    JO - Schizophrenia Bulletin

    JF - Schizophrenia Bulletin

    SN - 0586-7614

    IS - 4

    ER -