Build-a-cell: Engineering a synthetic cell community

Caroline Frischmon, Carlise Sorenson, Michael Winikoff, Katarzyna P. Adamala

Research output: Contribution to journalArticlepeer-review

Abstract

Build-a-Cell is a global network of researchers that aims to develop synthetic living cells within the next decade. These cells will revolutionize the biotechnology industry by providing scientists and engineers with a more complete understanding of biology. Researchers can already replicate many cellular functions individually, but combining them into a single cell remains a significant challenge. This integration step will require the type of large-scale collaboration made possible by Build-a-Cell’s open, collective structure. Beyond the lab, Build-a-Cell addresses policy issues and biosecurity concerns associated with synthetic cells. The following review discusses Build-a-Cell’s history, function, and goals.

Original languageEnglish (US)
Article number1176
JournalLife
Volume11
Issue number11
DOIs
StatePublished - Nov 2021

Bibliographical note

Funding Information:
This work was supported by the National Science Foundation Research Coordination Network award 1901145. We thank Marileen Dogterom, Drew Endy, John Glass, Anton Jackson-Smith, Richard Murray and Elibio Rech for interviews.

Funding Information:
Funding: This work was supported by the National Science Foundation Research Coordination Network award 1901145.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Artificial life
  • Bioengineering
  • Cell-free
  • Liposomes
  • Synthetic biology
  • Synthetic cells

PubMed: MeSH publication types

  • Journal Article

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