Brugada pattern electrocardiogram associated with supratherapeutic phenytoin levels and the risk of sudden death

Basel Al Aloul, A. Selcuk Adabag, Mark A. Houghland, Venkatakrishna Tholakanahalli

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The emergence of Brugada pattern on electrocardiogram in response to class IA or IC antiarrhythmic agents is widely utilized to diagnose concealed Brugada syndrome and recognized as a risk factor for sudden death. Phenytoin, a class IB antiarrhythmic agent, has not been reported to induce Brugada pattern. We report a patient who presented with Brugada electrocardiogram at supratherapeutic phenytoin level. Considering that patients with syncope may falsely be labeled to have seizures and some epilepsy patients are at increased risk of sudden death, all patients with supratherapeutic phenytoin level should be evaluated with an electrocardiogram for emergence of Brugada pattern.

Original languageEnglish (US)
Pages (from-to)713-715
Number of pages3
JournalPACE - Pacing and Clinical Electrophysiology
Volume30
Issue number5
DOIs
StatePublished - May 1 2007

Keywords

  • Electrocardiogram
  • Electrophysiology-clinical

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