Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes

Michael A. Via, Himani Chandra, Takako Araki, Matthew V. Potenza, Maria Skamagas

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Type 2 diabetes mellitus (T2DM) continues to rise in prevalence in the United States and worldwide. Despite advances in medical treatments for T2DM, many patients remain uncontrolled. By targeting centrally mediated pathways of glucose metabolism, bromocriptine represents a novel therapeutic option in T2DM. Several small clinical trials demonstrate improvements in insulin resistance and glycemic control. After the submission of data from four recent, large clinical trials, the US Food and Drug Administration has approved the use of bromocriptine in T2DM. We review the available data from these four trials and other published studies. Bromocriptine is a promising therapy for diabetes patients and demonstrates modest improvements in glycemic control.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Volume3
DOIs
StatePublished - 2010

Keywords

  • Bromocriptine
  • Diabetes
  • Dopamine agonists
  • Glycemic control

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