TY - JOUR
T1 - Broadband plasmonic-enhanced forward and backward multiplex coherent anti-Stokes Raman scattering microscopy
AU - Guo, Baoshan
AU - Jiang, Lan
AU - Hua, Yanhong
AU - Li, Xin
AU - Cui, Tianhong
AU - Lu, Yongfeng
N1 - Publisher Copyright:
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE).
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Coherent anti-Stokes Raman scattering (CARS) microscopy is an attractive technique for label-free biochemical-specific characterization of biological specimens. However, it has very low sensitivity in monitoring and imaging molecules present in extremely low concentrations or at fast speeds. To improve this sensitivity, especially for multiplex CARS, the intensity of the pump beam and broadband Stokes beam should be enhanced simultaneously. Therefore, the gold shell particle and gold surface are demonstrated to enhance the forward and backward CARS, respectively. Results show that a signal enhancement factor of ∼25,000 can be achieved for the gold surface and an even higher enhancement factor can be achieved for the gold shell particles. Thus, we can obtain an enhanced CARS signal in a broad spectral range, which will substantially improve the detection sensitivity of hyperspectral CARS spectroscopy and imaging.
AB - Coherent anti-Stokes Raman scattering (CARS) microscopy is an attractive technique for label-free biochemical-specific characterization of biological specimens. However, it has very low sensitivity in monitoring and imaging molecules present in extremely low concentrations or at fast speeds. To improve this sensitivity, especially for multiplex CARS, the intensity of the pump beam and broadband Stokes beam should be enhanced simultaneously. Therefore, the gold shell particle and gold surface are demonstrated to enhance the forward and backward CARS, respectively. Results show that a signal enhancement factor of ∼25,000 can be achieved for the gold surface and an even higher enhancement factor can be achieved for the gold shell particles. Thus, we can obtain an enhanced CARS signal in a broad spectral range, which will substantially improve the detection sensitivity of hyperspectral CARS spectroscopy and imaging.
KW - coherent anti-Stokes Raman scattering
KW - core-shell particles
KW - nanoparticles
KW - plasmonics
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U2 - 10.1117/1.OE.57.3.033105
DO - 10.1117/1.OE.57.3.033105
M3 - Article
AN - SCOPUS:85044577045
SN - 0091-3286
VL - 57
JO - Optical Engineering
JF - Optical Engineering
IS - 3
M1 - 033105
ER -