Broadband decoupled, 1H-localized 13C MRS of the human brain at 4 Tesla

Rolf Gruetter, Gregor Adriany, Hellmut Merkle, Peter M Andersen

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Abstract

Broadband proton decoupling of the entire 13C spectrum was possible within power absorption guidelines and resulted in the detection of narrow (as low as 2-3 Hz), natural abundance signals from metabolites such as myo- inositol, glutamate, N-acetyl-aspartate, and glutamine from 72 cm3 volumes in the human brain. To overcome the chemical shift displacement error, three- dimensional localization on the 1H z magnetization was combined with polarization transfer. Efficiency of the heteronuclear localization method was demonstrated by the elimination of all scalp lipid resonances. A signal- to-noise ratio of 5:1 for 0.07 mM [13C] was achieved in 12 min, which is approximately a fivefold improvement over the sensitivity reported at 2.1 Tesla.

Original languageEnglish (US)
Pages (from-to)659-664
Number of pages6
JournalMagnetic resonance in medicine
Volume36
Issue number5
DOIs
StatePublished - Nov 1 1996

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Keywords

  • C MRS
  • decoupling
  • human brain
  • polarization transfer

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