Abstract
Broadband proton decoupling of the entire 13C spectrum was possible within power absorption guidelines and resulted in the detection of narrow (as low as 2-3 Hz), natural abundance signals from metabolites such as myo- inositol, glutamate, N-acetyl-aspartate, and glutamine from 72 cm3 volumes in the human brain. To overcome the chemical shift displacement error, three- dimensional localization on the 1H z magnetization was combined with polarization transfer. Efficiency of the heteronuclear localization method was demonstrated by the elimination of all scalp lipid resonances. A signal- to-noise ratio of 5:1 for 0.07 mM [13C] was achieved in 12 min, which is approximately a fivefold improvement over the sensitivity reported at 2.1 Tesla.
Original language | English (US) |
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Pages (from-to) | 659-664 |
Number of pages | 6 |
Journal | Magnetic resonance in medicine |
Volume | 36 |
Issue number | 5 |
DOIs | |
State | Published - Nov 1996 |
Keywords
- C MRS
- decoupling
- human brain
- polarization transfer