Brief report: Molecular characterization of a novel reassorted pandemic H1N1 2009 in Thai pigs

Pravina Kitikoon, Donruethai Sreta, Suparlark Nuntawan Na Ayudhya, Manoosak Wongphatcharachai, Jiradej Lapkuntod, Duangduean Prakairungnamthip, Napawan Bunpapong, Sanipa Suradhat, Roongroje Thanawongnuwech, Alongkorn Amonsin

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

For the past 10 years, endemic swine influenza H1 viruses in Thailand have been characterized as reassortants of swine virus genes from swine influenza viruses (SIV) in US and European pigs. Here the authors report the emergence of a novel reassorted H1N1 (rH1N1) virus consisted of human, avian, and swine virus genes from the pandemic H1N1 2009 (pH1N1) virus with a neuraminidase (NA) gene from a Thai swine H1N1 (ThH1N1) isolate. The rH1N1 virus was detected in nursery pigs during a respiratory disease outbreak in central Thailand in early 2010. The rH1N1 virus was repeatedly isolated from infected pigs, suggesting that it can transmit efficiently among the pig population. The appearance of rH1N1 virus in the field occurred within months of the introduction of pH1N1 virus into the Thai swine population in late 2009. The finding highlights the role of pig in generating newly reassorted influenza A viruses and also the significance of continuing disease surveillance and genetic characterization of SIV in pigs.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalVirus Genes
Volume43
Issue number1
DOIs
StatePublished - Aug 2011
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgements The authors thank CU-EIDAs staffs for their dedicated assistant in sample collection and laboratory work. This study has been funded in whole with federal funds from the National Institute of Allergy and Infectious Disease, National Institute of Health, Department of Health and Human Services, under Contract no. HHSN266200700007c. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. The authors also would like to thank the National Research Council of Thailand (NRCT, Thailand) and the National Research University of CHE and the Ratchadaphiseksomphot Endowment Fund (HR1155A and HR1160A) for grant support to AA and RT. The authors are grateful thank to Chulalongkorn University Centenary Academic Development Project for supporting facilities to the Emerging and Re-emerging Infectious Disease in Animals, Research Unit. The authors would like to thank Ms. Petra Hirsch for reviewing the manuscript.

Keywords

  • Influenza
  • Pandemic H1N1 2009
  • Reassort
  • Swine
  • Thailand

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