Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β

Dejene M. Tufa; Fareed Ahmad; Debanjana Chatterjee; Gerrit Ahrenstorf; Reinhold E. Schmidt; Roland Jacobs

doi:10.1097/QAI.0000000000001082

Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β

Dejene M. Tufa
, Fareed Ahmad
, Debanjana Chatterjee
, Gerrit Ahrenstorf
, Reinhold E. Schmidt
, Roland Jacobs

Pediatric Blood & Marrow Transplant & Cellular Therapy

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1β during HIV-1 infection as compared with healthy controls. IL-1β plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection.

Original language	English (US)
Pages (from-to)	34-38
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes (1999)
Volume	73
Issue number	1
DOIs	https://doi.org/10.1097/QAI.0000000000001082
State	Published - Sep 1 2016

Bibliographical note

Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV
IL-1β
slanDCs

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10.1097/QAI.0000000000001082

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abstract = "HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1β during HIV-1 infection as compared with healthy controls. IL-1β plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection.",

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AU - Ahmad, Fareed

AU - Chatterjee, Debanjana

AU - Ahrenstorf, Gerrit

AU - Schmidt, Reinhold E.

AU - Jacobs, Roland

PY - 2016/9/1

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AB - HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1β during HIV-1 infection as compared with healthy controls. IL-1β plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection.

KW - HIV

KW - IL-1β

KW - slanDCs

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JF - Journal of Acquired Immune Deficiency Syndromes (1999)

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ER -

Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β

Abstract

Bibliographical note

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