Abstract
HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1β during HIV-1 infection as compared with healthy controls. IL-1β plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection.
Original language | English (US) |
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Pages (from-to) | 34-38 |
Number of pages | 5 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 73 |
Issue number | 1 |
DOIs | |
State | Published - Sep 1 2016 |
Bibliographical note
Publisher Copyright:Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Keywords
- HIV
- IL-1β
- slanDCs