Bridge to removal: A paradigm shift for left ventricular assist device therapy

Craig H. Selzman; Jesse L. Madden; Aaron H. Healy; Stephen H. McKellar; Antigone Koliopoulou; Josef Stehlik; Stavros G. Drakos

doi:10.1016/j.athoracsur.2014.07.061

Bridge to removal: A paradigm shift for left ventricular assist device therapy

Craig H. Selzman, Jesse L. Madden, Aaron H. Healy, Stephen H. McKellar, Antigone Koliopoulou, Josef Stehlik, Stavros G. Drakos

Surgery

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Abstract

Ventricular assist devices have become standard therapy for patients with advanced heart failure either as a bridge to transplantation or destination therapy. Despite the functional and biologic evidence of reverse cardiac remodeling, few patients actually proceed to myocardial recovery, and even fewer to the point of having their device explanted. An enhanced understanding of the biology and care of the mechanically supported patient has redirected focus on the possibility of using ventricular assist devices as a bridge to myocardial recovery and removal. Herein, we review the current issues and approaches to transforming myocardial recovery to a practical reality.

Original language	English (US)
Pages (from-to)	360-367
Number of pages	8
Journal	Annals of Thoracic Surgery
Volume	99
Issue number	1
DOIs	https://doi.org/10.1016/j.athoracsur.2014.07.061
State	Published - Jan 1 2015

Bibliographical note

Funding Information:
This work is funded, in part, by the National Institutes of Health , National Heart, Lung, and Blood Institute ( 4R01 HL089592 to C.H.S.), the Doris Duke Foundation Clinical Scientist Grant ( 2013108 to S.G.D.), a VA Merit Review Award ( 1I01CX000710-01A1 to J.S. and S.G.D.), and the Deseret Foundation ( 00571 to S.G.D.).

Publisher Copyright:
© 2015 The Society of Thoracic Surgeons.

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10.1016/j.athoracsur.2014.07.061

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title = "Bridge to removal: A paradigm shift for left ventricular assist device therapy",

abstract = "Ventricular assist devices have become standard therapy for patients with advanced heart failure either as a bridge to transplantation or destination therapy. Despite the functional and biologic evidence of reverse cardiac remodeling, few patients actually proceed to myocardial recovery, and even fewer to the point of having their device explanted. An enhanced understanding of the biology and care of the mechanically supported patient has redirected focus on the possibility of using ventricular assist devices as a bridge to myocardial recovery and removal. Herein, we review the current issues and approaches to transforming myocardial recovery to a practical reality.",

author = "Selzman, {Craig H.} and Madden, {Jesse L.} and Healy, {Aaron H.} and McKellar, {Stephen H.} and Antigone Koliopoulou and Josef Stehlik and Drakos, {Stavros G.}",

note = "Funding Information: This work is funded, in part, by the National Institutes of Health , National Heart, Lung, and Blood Institute ( 4R01 HL089592 to C.H.S.), the Doris Duke Foundation Clinical Scientist Grant ( 2013108 to S.G.D.), a VA Merit Review Award ( 1I01CX000710-01A1 to J.S. and S.G.D.), and the Deseret Foundation ( 00571 to S.G.D.). Publisher Copyright: {\textcopyright} 2015 The Society of Thoracic Surgeons.",

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T2 - A paradigm shift for left ventricular assist device therapy

AU - Selzman, Craig H.

AU - Madden, Jesse L.

AU - Healy, Aaron H.

AU - McKellar, Stephen H.

AU - Koliopoulou, Antigone

AU - Stehlik, Josef

AU - Drakos, Stavros G.

N1 - Funding Information: This work is funded, in part, by the National Institutes of Health , National Heart, Lung, and Blood Institute ( 4R01 HL089592 to C.H.S.), the Doris Duke Foundation Clinical Scientist Grant ( 2013108 to S.G.D.), a VA Merit Review Award ( 1I01CX000710-01A1 to J.S. and S.G.D.), and the Deseret Foundation ( 00571 to S.G.D.). Publisher Copyright: © 2015 The Society of Thoracic Surgeons.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Ventricular assist devices have become standard therapy for patients with advanced heart failure either as a bridge to transplantation or destination therapy. Despite the functional and biologic evidence of reverse cardiac remodeling, few patients actually proceed to myocardial recovery, and even fewer to the point of having their device explanted. An enhanced understanding of the biology and care of the mechanically supported patient has redirected focus on the possibility of using ventricular assist devices as a bridge to myocardial recovery and removal. Herein, we review the current issues and approaches to transforming myocardial recovery to a practical reality.

AB - Ventricular assist devices have become standard therapy for patients with advanced heart failure either as a bridge to transplantation or destination therapy. Despite the functional and biologic evidence of reverse cardiac remodeling, few patients actually proceed to myocardial recovery, and even fewer to the point of having their device explanted. An enhanced understanding of the biology and care of the mechanically supported patient has redirected focus on the possibility of using ventricular assist devices as a bridge to myocardial recovery and removal. Herein, we review the current issues and approaches to transforming myocardial recovery to a practical reality.

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Bridge to removal: A paradigm shift for left ventricular assist device therapy

Abstract

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