Breast cancer, stem/progenitor cells and the estrogen receptor

Gabriela Dontu; Dorraya El-Ashry; Max S. Wicha

doi:10.1016/j.tem.2004.05.011

Breast cancer, stem/progenitor cells and the estrogen receptor

Gabriela Dontu
, Dorraya El-Ashry
, Max S. Wicha

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

274 Scopus citations

Abstract

Recently, substantial progress has been made in the identification and characterization of stem and progenitor cells in the mouse and human mammary gland. Furthermore, there is accumulating evidence that these cells might be targets for transformation during mammary carcinogenesis. On the basis of this stem cell concept, we propose a model in which the transformation of different subsets of stem and progenitor cells results in the diversity of breast cancer phenotypes, including expression of the estrogen receptor in breast cancers subtypes. This model has important implications for understanding mammary carcinogenesis. Furthermore, the concept of breast cancer as a disease of mammary stem and progenitor cells has profound implications for the development of new strategies for breast cancer prevention and therapy.

Original language	English (US)
Pages (from-to)	193-197
Number of pages	5
Journal	Trends in Endocrinology and Metabolism
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.tem.2004.05.011
State	Published - Jul 2004

Bibliographical note

Funding Information:
Thanks to Dr Daniel Hayes, Dr Kathleen Ignatoski and Mari Kawamura for critical review of the manuscript. This work was supported by NIH grant CCA66233.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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title = "Breast cancer, stem/progenitor cells and the estrogen receptor",

abstract = "Recently, substantial progress has been made in the identification and characterization of stem and progenitor cells in the mouse and human mammary gland. Furthermore, there is accumulating evidence that these cells might be targets for transformation during mammary carcinogenesis. On the basis of this stem cell concept, we propose a model in which the transformation of different subsets of stem and progenitor cells results in the diversity of breast cancer phenotypes, including expression of the estrogen receptor in breast cancers subtypes. This model has important implications for understanding mammary carcinogenesis. Furthermore, the concept of breast cancer as a disease of mammary stem and progenitor cells has profound implications for the development of new strategies for breast cancer prevention and therapy.",

author = "Gabriela Dontu and Dorraya El-Ashry and Wicha, \{Max S.\}",

note = "Funding Information: Thanks to Dr Daniel Hayes, Dr Kathleen Ignatoski and Mari Kawamura for critical review of the manuscript. This work was supported by NIH grant CCA66233.",

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AU - Dontu, Gabriela

AU - El-Ashry, Dorraya

AU - Wicha, Max S.

N1 - Funding Information: Thanks to Dr Daniel Hayes, Dr Kathleen Ignatoski and Mari Kawamura for critical review of the manuscript. This work was supported by NIH grant CCA66233.

PY - 2004/7

Y1 - 2004/7

N2 - Recently, substantial progress has been made in the identification and characterization of stem and progenitor cells in the mouse and human mammary gland. Furthermore, there is accumulating evidence that these cells might be targets for transformation during mammary carcinogenesis. On the basis of this stem cell concept, we propose a model in which the transformation of different subsets of stem and progenitor cells results in the diversity of breast cancer phenotypes, including expression of the estrogen receptor in breast cancers subtypes. This model has important implications for understanding mammary carcinogenesis. Furthermore, the concept of breast cancer as a disease of mammary stem and progenitor cells has profound implications for the development of new strategies for breast cancer prevention and therapy.

AB - Recently, substantial progress has been made in the identification and characterization of stem and progenitor cells in the mouse and human mammary gland. Furthermore, there is accumulating evidence that these cells might be targets for transformation during mammary carcinogenesis. On the basis of this stem cell concept, we propose a model in which the transformation of different subsets of stem and progenitor cells results in the diversity of breast cancer phenotypes, including expression of the estrogen receptor in breast cancers subtypes. This model has important implications for understanding mammary carcinogenesis. Furthermore, the concept of breast cancer as a disease of mammary stem and progenitor cells has profound implications for the development of new strategies for breast cancer prevention and therapy.

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AN - SCOPUS:3042525924

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JF - Trends in Endocrinology and Metabolism

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ER -

Breast cancer, stem/progenitor cells and the estrogen receptor

Abstract

Bibliographical note

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