Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists

Parveen Bhatti, Michele M. Doody, Bruce H. Alexander, Jeff Yuenger, Steven L. Simon, Robert M. Weinstock, Marvin Rosenstein, Marilyn Stovall, Michael Abend, Dale L. Preston, Paul Pharoah, Jeffery P. Struewing, Alice J. Sigurdson

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P interaction = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway.

Original languageEnglish (US)
Pages (from-to)2007-2011
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume17
Issue number8
DOIs
StatePublished - Aug 2008

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