Breaking the NF-κB and STAT3 alliance inhibits inflammation and pancreatic tumorigenesis

Young Joon Surh, Ann M. Bode, Zigang Dong

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

This perspective on Liby et al. (beginning on page 1427 in this issue of the journal) discusses the importance of the finding that two synthetic triterpenoids prolonged survival in a pancreatic cancer mouse model. This finding is significant because pancreatic cancer is one of the deadliest human cancers. These compounds inhibited the interaction between NF-κB and signal transducer and activator of transcription 3, and determining the mechanisms underlying this inhibition will help to rapidly move these compounds into phase I clinical trials.

Original languageEnglish (US)
Pages (from-to)1379-1381
Number of pages3
JournalCancer Prevention Research
Volume3
Issue number11
DOIs
StatePublished - Nov 2010

Fingerprint

Dive into the research topics of 'Breaking the NF-κB and STAT3 alliance inhibits inflammation and pancreatic tumorigenesis'. Together they form a unique fingerprint.

Cite this