Brain morphometry using diffusion-weighted magnetic resonance imaging: Application to schizophrenia

Babak A. Ardekani, Arthika Bappal, Debra D'Angelo, Manzar Ashtari, Todd Lencz, Philip R. Szeszko, Pamela D. Butler, Daniel C. Javitt, Kelvin O. Lim, Jan Hrabe, Jay Nierenberg, Craig A. Branch, Matthew J. Hoptman

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Loss of cortical gray matter is accompanied by a commensurate increase in the sulcal and intraventricular cerebrospinal fluid volume. On diffusion-weighted magnetic resonance imaging, this would be reflected as a higher apparent diffusion coefficient in affected brain regions. On the basis of the above premise, we suggest that the apparent diffusion coefficient may be used as a surrogate marker for the assessment of regional brain volume deficits. We demonstrate this approach by voxelwise analysis of registered apparent diffusion coefficient images from a group of 15 patients with schizophrenia and 15 age-matched healthy controls. We found widespread regional apparent diffusion coefficient increases in patients. Affected areas included the bilateral insular cortex, hippocampus, temporal lobe, and occipital areas. These results largely concur with previous findings of cortical volume deficits in schizophrenia.

Original languageEnglish (US)
Pages (from-to)1455-1459
Number of pages5
Issue number13
StatePublished - Sep 8 2005


  • Apparent diffusion coefficient
  • Brain
  • Diffusion-weighted magnetic resonance imaging
  • Magnetic resonance imaging
  • Morphometry
  • Schizophrenia


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