Brain lactate during partial global ischemia and reperfusion: Effect of pretreatment with dichloroacetate in a rat model

Michelle H. Biros, Ruth V W Dimlich

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Elevated cerebral lactate levels following cerebral ischemia have been associated with brain cell damage and death. We previously found that pre- or postischemia treatment with dichloroacetate (DCA), presumably by its activation of brain pyruvate dehydrogenase, effectively lowers cerebral lactate levels in rats subjected to 30 minutes of partial global ischemia (PGI) followed by 30 minutes of recirculation. The goal of the present study was to determine the effects of preischemia DCA treatment on cortical lactate levels during the ischemia period or during early recirculation. Rats (four in each group) received preischemia treatment with DCA and were then subjected to 0, 10, or 30 minutes of PGI or 30 minutes of PGI followed by 15 minutes of recirculation. Cortical lactate levels in pretreated aminals were not significantly different from lactate levels of untreated rats at any time during PGI, but were significantly lower than levels in untreated rats at 15 minutes of recirculation (P < .05, ANOVA). These results suggest that preischemia treatment with DCA does not limit the accumulation of cortical lactate during PGI but may promote its clearance during recirculation following PGI. If reperfusion events influence the degree of brain cell injury, DCA may enhance cell recovery by lower cortical lactate levels in the reperfusion period.

Original languageEnglish (US)
Pages (from-to)271-277
Number of pages7
JournalAmerican Journal of Emergency Medicine
Volume5
Issue number4
DOIs
StatePublished - Jul 1987

Keywords

  • Brain lactate
  • dichloroacetate
  • partial global ischemia

Fingerprint Dive into the research topics of 'Brain lactate during partial global ischemia and reperfusion: Effect of pretreatment with dichloroacetate in a rat model'. Together they form a unique fingerprint.

Cite this