Brain arterial dilatation and the risk of Alzheimer's disease

Jose Gutierrez; Vanessa Guzman; Farid Khasiyev; Jennifer Manly; Nicole Schupf; Howard Andrews; Richard Mayeux; Adam M. Brickman

doi:10.1016/j.jalz.2018.12.018

Brain arterial dilatation and the risk of Alzheimer's disease

Jose Gutierrez, Vanessa Guzman, Farid Khasiyev, Jennifer Manly, Nicole Schupf, Howard Andrews, Richard Mayeux, Adam M. Brickman

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Introduction: We tested the hypothesis that brain arterial dilatation increases the risk of Alzheimer's dementia (AD). Methods: We studied dementia-free participants in the Washington Heights-Inwood Columbia Aging Project who had a brain MRI and post-MRI dementia adjudication. We measured the axial T2-proton density diameters of the intracranial carotids and basilar diameters and used Cox models to obtain AD hazard ratios and 95% intervals. Results: Of 953 participants (mean age 77 ± 7 y, women 64%, 71% nonwhite)followed on average for 3 ± 3 years, 76 (8%)developed AD. In a model adjusted for demographics, vascular risks, apolipoprotein E (APOE)-ε4, and white matter hyperintensities, larger carotid diameters increased the risk of AD, defined categorically as ≥ 90th percentile (HR 4.34, 1.70–11.11)or continuously (HR 1.44 per SD, 1.07–1.94). Discussion: Understanding the pathophysiology of the association between AD and brain arterial dilatation may reveal new clues to the vascular contributions to AD.

Original language	English (US)
Pages (from-to)	666-674
Number of pages	9
Journal	Alzheimer's and Dementia
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.jalz.2018.12.018
State	Published - May 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 the Alzheimer's Association

Keywords

Alzheimer's disease
Brain arterial diameters
Brain arterial dilatation
Carotid artery
Dementia
Dolichoectasia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.jalz.2018.12.018

Find It

Find It at U of M Libraries

Cite this

@article{bc2a9673861b4faf87d0188386359683,

title = "Brain arterial dilatation and the risk of Alzheimer's disease",

abstract = "Introduction: We tested the hypothesis that brain arterial dilatation increases the risk of Alzheimer's dementia (AD). Methods: We studied dementia-free participants in the Washington Heights-Inwood Columbia Aging Project who had a brain MRI and post-MRI dementia adjudication. We measured the axial T2-proton density diameters of the intracranial carotids and basilar diameters and used Cox models to obtain AD hazard ratios and 95\% intervals. Results: Of 953 participants (mean age 77 ± 7 y, women 64\%, 71\% nonwhite)followed on average for 3 ± 3 years, 76 (8\%)developed AD. In a model adjusted for demographics, vascular risks, apolipoprotein E (APOE)-ε4, and white matter hyperintensities, larger carotid diameters increased the risk of AD, defined categorically as ≥ 90th percentile (HR 4.34, 1.70–11.11)or continuously (HR 1.44 per SD, 1.07–1.94). Discussion: Understanding the pathophysiology of the association between AD and brain arterial dilatation may reveal new clues to the vascular contributions to AD.",

keywords = "Alzheimer's disease, Brain arterial diameters, Brain arterial dilatation, Carotid artery, Dementia, Dolichoectasia",

author = "Jose Gutierrez and Vanessa Guzman and Farid Khasiyev and Jennifer Manly and Nicole Schupf and Howard Andrews and Richard Mayeux and Brickman, \{Adam M.\}",

note = "Publisher Copyright: {\textcopyright} 2019 the Alzheimer's Association",

year = "2019",

month = may,

doi = "10.1016/j.jalz.2018.12.018",

language = "English (US)",

volume = "15",

pages = "666--674",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley and Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Brain arterial dilatation and the risk of Alzheimer's disease

AU - Gutierrez, Jose

AU - Guzman, Vanessa

AU - Khasiyev, Farid

AU - Manly, Jennifer

AU - Schupf, Nicole

AU - Andrews, Howard

AU - Mayeux, Richard

AU - Brickman, Adam M.

PY - 2019/5

Y1 - 2019/5

N2 - Introduction: We tested the hypothesis that brain arterial dilatation increases the risk of Alzheimer's dementia (AD). Methods: We studied dementia-free participants in the Washington Heights-Inwood Columbia Aging Project who had a brain MRI and post-MRI dementia adjudication. We measured the axial T2-proton density diameters of the intracranial carotids and basilar diameters and used Cox models to obtain AD hazard ratios and 95% intervals. Results: Of 953 participants (mean age 77 ± 7 y, women 64%, 71% nonwhite)followed on average for 3 ± 3 years, 76 (8%)developed AD. In a model adjusted for demographics, vascular risks, apolipoprotein E (APOE)-ε4, and white matter hyperintensities, larger carotid diameters increased the risk of AD, defined categorically as ≥ 90th percentile (HR 4.34, 1.70–11.11)or continuously (HR 1.44 per SD, 1.07–1.94). Discussion: Understanding the pathophysiology of the association between AD and brain arterial dilatation may reveal new clues to the vascular contributions to AD.

AB - Introduction: We tested the hypothesis that brain arterial dilatation increases the risk of Alzheimer's dementia (AD). Methods: We studied dementia-free participants in the Washington Heights-Inwood Columbia Aging Project who had a brain MRI and post-MRI dementia adjudication. We measured the axial T2-proton density diameters of the intracranial carotids and basilar diameters and used Cox models to obtain AD hazard ratios and 95% intervals. Results: Of 953 participants (mean age 77 ± 7 y, women 64%, 71% nonwhite)followed on average for 3 ± 3 years, 76 (8%)developed AD. In a model adjusted for demographics, vascular risks, apolipoprotein E (APOE)-ε4, and white matter hyperintensities, larger carotid diameters increased the risk of AD, defined categorically as ≥ 90th percentile (HR 4.34, 1.70–11.11)or continuously (HR 1.44 per SD, 1.07–1.94). Discussion: Understanding the pathophysiology of the association between AD and brain arterial dilatation may reveal new clues to the vascular contributions to AD.

KW - Alzheimer's disease

KW - Brain arterial diameters

KW - Brain arterial dilatation

KW - Carotid artery

KW - Dementia

KW - Dolichoectasia

UR - https://www.scopus.com/pages/publications/85062080826

UR - https://www.scopus.com/inward/citedby.url?scp=85062080826&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2018.12.018

DO - 10.1016/j.jalz.2018.12.018

M3 - Article

C2 - 30827874

AN - SCOPUS:85062080826

SN - 1552-5260

VL - 15

SP - 666

EP - 674

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 5

ER -

Brain arterial dilatation and the risk of Alzheimer's disease

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this