Bradykinin and inflammatory pain

K. M. Hargreaves, M. T. Roszkowski, James Q Swift

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


The pro-inflammatory pharmacology of bradykinin has been well established. However, knowledge of the actual tissue concentrations and pharmacological manipulation of immunoreactive bradykinin in clinical and animal models of inflammation remain relatively sparse. We have developed a microdialysis method to implant probes into the inflamed tissue compartment in order to collect dialysate continuously in patients following the surgical removal of impacted third molars. Dialysate samples can be analyzed for levels of inflammatory mediators (eg., bradykinin, prostaglandins, etc) and drugs in order to determine the time-response curves for local release of substances in inflamed tissue.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalAgents and Actions
Issue numberSUPPL.
StatePublished - Jan 1 1993


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