Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

Guang Wu Zhang; Dong Hua Zheng; Jing Nie; Teng Wang; Jun An Ma

doi:10.1039/b924272d

Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

Guang Wu Zhang
, Dong Hua Zheng
, Jing Nie
, Teng Wang
, Jun An Ma

Institute for Therapeutics Discovery and Development

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.

Original language	English (US)
Pages (from-to)	1399-1405
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	8
Issue number	6
DOIs	https://doi.org/10.1039/b924272d
State	Published - Mar 12 2010

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10.1039/b924272d

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title = "Br{\o}nsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide",

abstract = "A general method for the one-pot, three-component Strecker reaction of ketones was developed using Br{\o}nsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79-99\%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40\% ee) is also described.",

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T1 - Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

AU - Zhang, Guang Wu

AU - Zheng, Dong Hua

AU - Nie, Jing

AU - Wang, Teng

AU - Ma, Jun An

PY - 2010/3/12

Y1 - 2010/3/12

N2 - A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.

AB - A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.

UR - https://www.scopus.com/pages/publications/77749289905

UR - https://www.scopus.com/pages/publications/77749289905#tab=citedBy

U2 - 10.1039/b924272d

DO - 10.1039/b924272d

M3 - Article

C2 - 20204214

AN - SCOPUS:77749289905

SN - 1477-0520

VL - 8

SP - 1399

EP - 1405

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 6

ER -

Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

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