Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

Guang Wu Zhang, Dong Hua Zheng, Jing Nie, Teng Wang, Jun An Ma

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.

Original languageEnglish (US)
Pages (from-to)1399-1405
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume8
Issue number6
DOIs
StatePublished - Mar 12 2010

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