(-)-Botryodiplodin, a unique ribose-analog toxin

W. Thomas Shier, Hamed K. Abbas, Richard E. Baird, Mohammad Ramezani, Gabriel L. Sciumbato

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Frequently toxins are structural analogs of essential metabolites, acting by interfering with normal metabolism. Because ribose derivatives play critical roles in information storage, energy currency, and photosynthesis, ribose should provide the basis for a toxic analog mechanism. The only known simple ribose-analog toxin, (-)-botryodiplodin, exhibits anticancer, antibacterial, antifungal, phytotoxic, mitogenic, and antifertility activities, and may play a role in plant diseases. Unusual structural properties allow oligomerization of (-)-botryodiplodin to pigments and cross-linking agents, which may be responsible for some of its biological activities, but there is no evidence that (-)-botryodiplodin or any other known toxin acts by a ribose-analog mechanism.

Original languageEnglish (US)
Pages (from-to)343-386
Number of pages44
JournalToxin Reviews
Volume26
Issue number4
DOIs
StatePublished - Oct 2007

Bibliographical note

Funding Information:
This work was supported in part by the Mississippi Soybean Promotion Board and the Mississippi State University Research Initiatives grants program.

Keywords

  • Anti-cancer agents
  • Botryodiplodin
  • Charcoal rot disease
  • Cross-linking agents
  • Phaseolinone
  • Ribose-analog toxin

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