Bone-muscle indices as risk factors for fractures in Men: The osteoporotic fractures in men (MrOS) study

A. K.O. Wong, P. M. Cawthon, K. W. Peters, S. R. Cummings, C. L. Gordon, Y. Sheu, Kristine E Ensrud, M. Petit, J. M. Zmuda, E. Orwoll, J. Cauley

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: To assess bone-muscle (B-M) indices as risk factors for incident fractures in men.

Methods: Participants of the Osteoporotic Fractures in Men (MrOS) Study completed a peripheral quantitative computed tomography scan at 66% of their tibial length. Bone macrostructure, estimates of bone strength, and muscle area were computed. Areal bone mineral density (aBMD) and body composition were assessed with dual-energy X-ray absorptiometry. Four year incident non-spine and clinical vertebral fractures were ascertained. B-M indices were expressed as bone-to-muscle ratios for: strength, mass and area. Discriminative power and hazards ratios (HR) for fractures were reported.

Results: In 1163 men (age: 77.2±5.2 years, body mass index (BMI): 28.0±4.0 kg/m2, 4.1±0.9 follow-up years, 7.7% of men ≥1 fracture), B-M indices were smaller in fractured men except for bending and areal indices. Smaller B-M indices were associated with increased fracture risk (HR: 1.30 to 1.74) independent of age and BMI. Strength and mass indices remained significant after accounting for lumbar spine but not total hip aBMD. However, aBMD correlated significantly with B-M indices.

Conclusion: Mass and bending B-M indices are risk factors for fractures in men, but may not improve fracture risk prediction beyond that provided by total hip aBMD.

Original languageEnglish (US)
Pages (from-to)246-254
Number of pages9
JournalJournal of Musculoskeletal Neuronal Interactions
Issue number3
StatePublished - Sep 1 2014

Bibliographical note

Publisher Copyright:
© 2014, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.


  • Bone-Muscle indices
  • DXA
  • Discriminative power
  • Full body composition
  • Incident fractures
  • Men
  • Osteoporosis
  • pQCT


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