Bone morphogenetic proteins

Their role in regulating osteoclast differentiation

Research output: Contribution to journalReview article

Abstract

The ability to create recombinant bone morphogenetic proteins (BMPs)in recent years has led to their rise as a common clinical adjuvant. Their application varies, from spinal fixation to repairing palatal clefts, to coating implants for osseointegration. In recent years questions have been raised as to the efficacy of BMPs in several of these procedures. These questions are due to the unwanted side effect of BMPs on other cell types, such as osteoclasts which can resorb bone at the graft/implant site. However, most BMP research focuses on the anabolic osteoinductive effects of BMPs on osteoblasts rather than its counterpart- stimulation of the osteoclasts, which are cells responsible for resorbing bone. In this review, we discuss the data available from multiple in-vitro and in-vivo BMP-related knockout models to elucidate the different functions BMPs have on osteoclast differentiation and activity.

Original languageEnglish (US)
Article number100207
JournalBone Reports
Volume10
DOIs
StatePublished - Jun 1 2019

Fingerprint

Bone Morphogenetic Proteins
Osteoclasts
Osseointegration
Anabolic Agents
Bone and Bones
Osteoblasts
Recombinant Proteins
Transplants
Research

Keywords

  • BMP
  • Coupling
  • MAPK
  • Osteoclasts
  • Receptors
  • SMAD1/5

Cite this

Bone morphogenetic proteins : Their role in regulating osteoclast differentiation. / Huntley, Raphael; Jensen, Eric D; Gopalakrishnan, Rajaram; Mansky, Kim.

In: Bone Reports, Vol. 10, 100207, 01.06.2019.

Research output: Contribution to journalReview article

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