Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

Aaron Broege, Lan Pham, Eric D. Jensen, Ann Emery, Tsang Hai Huang, Melissa Stemig, Hideyuki Beppu, Anna Petryk, Michael O'Connor, Kim Mansky, Raj Gopalakrishnan

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.

Original languageEnglish (US)
Pages (from-to)37230-37240
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number52
DOIs
StatePublished - Dec 27 2013

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