Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion

J. M. Goldman, R. P. Gale, M. M. Horowitz, J. C. Biggs, R. E. Champlin, E. Gluckman, R. G. Hoffmann, S. J. Jacobsen, A. M. Marmont, P. B. McGlave, H. A. Messner, A. A. Rimm, C. Rozman, B. Speck, S. Tura, R. S. Weiner, M. M. Bortin

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Abstract

Data on 405 patients with chronic myelogenous leukemia who received bone marrow transplants in chronic phase were analyzed for factors predictive of outcome. The 4-year actuarial probability of relapse was 19% (95% confidence interval [Cl], 12% to 28%) and of survival, 55% (95% Cl, 50% to 60%). In multivariate analyses the probability of relapse was higher for recipients of T-cell-depleted bone marrow compared with recipients of non-T-cell-depleted bone marrow (relative risk, 5.4; P < 0.0001) and for patients who did not develop chronic graft-versus-host disease with patients who did (relative risk, 3.1; P < 0.01). The probability of survival was lower for patients who developed moderate to severe acute graft-versus-host disease than for patients with no or mild acute graft-versus-host disease (relative risk, 3.7; P < 0.0001), and in patients aged 20 or older than in younger patients (relative risk, 2.6; P < 0.0002). Duration of disease before transplant was not associated with outcome. Bone marrow transplantation done in the chronic phase of chronic myelogenous leukemia offers some patients prolonged leukemia-free survival. The T-cell-depleted grafts are associated with an increased probability of relapse.

Original languageEnglish (US)
Pages (from-to)806-814
Number of pages9
JournalAnnals of internal medicine
Volume108
Issue number6
DOIs
StatePublished - 1988

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