Bone formation on carbon nanotube composite

Mrinal Bhattacharya, Patcharaporn Wutticharoenmongkol-Thitiwongsawet, Darryl T. Hamamoto, Dongjin Lee, Tianhong Cui, Hari S. Prasad, Mansur Ahmad

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


The effects of a layer-by-layer assembled carbon nanotube composite (CNT-comp) on osteoblasts in vitro and bone tissue in vivo in rats were studied. The effects of CNT-comp on osteoblasts were compared against the effects by commercially pure titanium (cpTi) and tissue culture dishes. Cell proliferation on the CNT-comp and cpTi were similar. However, cell differentiation, measured by alkaline phosphatase activity and matrix mineralization, was better on the CNT-comp. When implanted in critical-sized rat calvarial defect, the CNT-comp permitted bone formation and bone repair without signs of rejection or inflammation. These data indicate that CNT-comp may be a promising substrate for use as a bone implant or as a scaffold for tissue engineering.

Original languageEnglish (US)
Pages (from-to)75-82
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume96 A
Issue number1
StatePublished - Jan 1 2011


  • carbon nanotube
  • critical sized defect
  • mineralization
  • osteoblast
  • titanium


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