Abstract
Skeletal disease-induced bone defect repair has driven the demand for bone grafts. The synthetic group of bone graft substitutes provides an alternative to allo/auto grafts, which can present problems of rejection, infection and host site trauma. Bioactive glasses undergo dynamic changes in vivo to produce a bone like apatite layer permitting a strong bond with living bone, and their compositions can be modified and tailored, to meet specific requirements, such as to be osteoinductive, antibacterial and even stimulate angiogenesis. This Chapter provides the background information of bone biology, including bone structure from macro- to nanoscale, blood supply, cell types, matrix, biomineralization and bone remodeling, to describe the biological basis of bone grafts, in particular, the application for periodontal defective bone repair. Then the bioactive glass history, bioactivity, advantages and limitations are discussed.
| Original language | English (US) |
|---|---|
| Title of host publication | Bone Regeneration |
| Subtitle of host publication | Concepts, Clinical Aspects and Future Directions |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 255-280 |
| Number of pages | 26 |
| ISBN (Electronic) | 9781536139914 |
| ISBN (Print) | 9781536139907 |
| State | Published - Jul 12 2018 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018 Nova Science Publishers, Inc. All rights reserved.
Keywords
- Bioactive glass
- Bone
- Bone graft
- Periodontal regeneration