Bold-fMRI response to single-pulse transcranial magnetic stimulation (TMS)

Daryl E. Bohning, Ananda Shastri, Eric M. Wassermann, Ulf Ziemann, Jeffrey P. Lorberbaum, Ziad Nahas, Mikhail P. Lomarev, Mark S. George

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


Five healthy volunteers were studied using interleaved transcranial magnetic stimulation/functional magnetic resonance imaging (TMS/fMRI) and an averaged single trial (AST) protocol. Blood oxygenation level-dependent (BOLD)-fMRI response to single TMS pulses over the motor cortex was detectable in both the ipsilateral motor cortex under the TMS coil and the contralateral motor cortex, as well as bilaterally in the auditory cortex. The associated BOLD signal increase showed the typical fMRI hemodynamic response time course. The brain's response to a single TMS pulse over the motor cortex at 120% of the level required to induce thumb movement (1.0%- 1.5% signal increase) was comparable in both level and duration to the auditory cortex response to the sound accompanying the TMS pulse (1.5%-2.0% signal increase). (C) 200 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)569-574
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Issue number6
StatePublished - Jun 1 2000


  • Imaging
  • Motor cortex
  • Single-event fMRI
  • Single-pulse transcranial magnetic stimulation (TMS)


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