Body-wall muscle formation in Caenorhabditis elegans embryos that lack the myoD homolog hlh-1

Lihsia Chen, Michael Krause, Bruce Draper, Harold Weintraub, Andrew Fire

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The myoD family of DNA binding proteins has been implicated in the control of myogenesis in a variety of organisms. Searches for homologs in the nematode Caenorhabditis elegans yielded only one gene, designated hlh-1, expressed in body-wall muscle cells and their precursors. To assess the role of hlh-1 in C. elegans myogenesis, genetic deficiencies spanning the hlh-1 locus were isolated after gamma irradiation. Embryos homozygous for these deficiencies exhibited extensive body-wall muscle differentiation, including expression of several characteristic myofilament proteins and weak contracile behavior. Thus, zygotic hlh-1 expression was not required for body-wall muscle precursors to adopt muscle cell fates.

Original languageEnglish (US)
Pages (from-to)240-243
Number of pages4
JournalScience
Volume256
Issue number5054
DOIs
StatePublished - Jan 1 1992

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Muscle Development
Caenorhabditis elegans
Embryonic Structures
Muscles
Myofibrils
Myoblasts
DNA-Binding Proteins
Muscle Cells
Genes
Proteins

Cite this

Body-wall muscle formation in Caenorhabditis elegans embryos that lack the myoD homolog hlh-1. / Chen, Lihsia; Krause, Michael; Draper, Bruce; Weintraub, Harold; Fire, Andrew.

In: Science, Vol. 256, No. 5054, 01.01.1992, p. 240-243.

Research output: Contribution to journalArticle

Chen, Lihsia ; Krause, Michael ; Draper, Bruce ; Weintraub, Harold ; Fire, Andrew. / Body-wall muscle formation in Caenorhabditis elegans embryos that lack the myoD homolog hlh-1. In: Science. 1992 ; Vol. 256, No. 5054. pp. 240-243.
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