Body composition and cognition in preschool-age children with congenital gastrointestinal anomalies

Erin A. Plummer; Qi Wang; Catherine M. Larson-Nath; Johannah M. Scheurer; Sara E. Ramel

doi:10.1016/j.earlhumdev.2018.12.001

Body composition and cognition in preschool-age children with congenital gastrointestinal anomalies

Erin A. Plummer, Qi Wang, Catherine M. Larson-Nath, Johannah M. Scheurer, Sara E. Ramel

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Children with congenital gastrointestinal anomalies (CGIAs) experience multiple stressors while hospitalized in neonatal intensive care units during an essential time of growth and development. Early stress and inadequate nutrition are linked to altered growth patterns and later neurodevelopmental delays. In other at-risk populations, improved fat-free mass (FFM) accretion is associated with improved cognitive outcomes. Objective: To determine if body composition is associated with cognitive function in preschool-age children with CGIAs. Study design: An observational study examined body composition and cognition in 34 preschool-age children with CGIAs. Anthropometric measurements and body composition testing via air displacement plethysmography were obtained. Measurements were compared with a reference group of healthy, term-born children. Cognition was measured with the NIH Toolbox Early Childhood Cognition Battery. Linear regression was used to test the association of body composition with cognitive function. Results: Compared with the reference group, children with CGIAs had similar anthropometric measurements (weight, height, and body mass index z-scores) and body composition at preschool-age. Processing speed scores were lower than standardized means (p = 0.001). Increased FFM was associated with higher receptive vocabulary scores (p = 0.001), cognitive flexibility scores (p = 0.005), and general cognitive function scores (p = 0.05). Conclusions: At preschool-age, children with CGIAs have similar growth and body composition to their peers. In children with CGIAs, higher FFM was associated with higher cognitive scores. Closer tracking of body composition and interventions aimed at increasing FFM may improve long-term outcomes in this population.

Original language	English (US)
Pages (from-to)	5-10
Number of pages	6
Journal	Early Human Development
Volume	129
DOIs	https://doi.org/10.1016/j.earlhumdev.2018.12.001
State	Published - Feb 2019

Bibliographical note

Funding Information:
Funding for the project was from the Benjamin Walker Hanson Fund of the University of Minnesota Foundation and the Center for Neurobehavioral Development Seed Grant . The Center for Neurobehavioral Development at the University of Minnesota provided research space. Statistical analysis was performed through The Biostatistical Design and Analysis Center of The Clinical and Translational Science Institute of the University of Minnesota.

Funding Information:
The authors have no conflicts of interest to report. Funding for the project was from the Benjamin Walker Hanson Fund of the University of Minnesota Foundation and the Center for Neurobehavioral Development Seed Grant.

Keywords

Body composition
Fat-free mass
Inflammation
Neonatal surgery
Neurodevelopment
Outcomes

PubMed: MeSH publication types

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

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10.1016/j.earlhumdev.2018.12.001

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382521

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title = "Body composition and cognition in preschool-age children with congenital gastrointestinal anomalies",

abstract = "Background: Children with congenital gastrointestinal anomalies (CGIAs) experience multiple stressors while hospitalized in neonatal intensive care units during an essential time of growth and development. Early stress and inadequate nutrition are linked to altered growth patterns and later neurodevelopmental delays. In other at-risk populations, improved fat-free mass (FFM) accretion is associated with improved cognitive outcomes. Objective: To determine if body composition is associated with cognitive function in preschool-age children with CGIAs. Study design: An observational study examined body composition and cognition in 34 preschool-age children with CGIAs. Anthropometric measurements and body composition testing via air displacement plethysmography were obtained. Measurements were compared with a reference group of healthy, term-born children. Cognition was measured with the NIH Toolbox Early Childhood Cognition Battery. Linear regression was used to test the association of body composition with cognitive function. Results: Compared with the reference group, children with CGIAs had similar anthropometric measurements (weight, height, and body mass index z-scores) and body composition at preschool-age. Processing speed scores were lower than standardized means (p = 0.001). Increased FFM was associated with higher receptive vocabulary scores (p = 0.001), cognitive flexibility scores (p = 0.005), and general cognitive function scores (p = 0.05). Conclusions: At preschool-age, children with CGIAs have similar growth and body composition to their peers. In children with CGIAs, higher FFM was associated with higher cognitive scores. Closer tracking of body composition and interventions aimed at increasing FFM may improve long-term outcomes in this population.",

keywords = "Body composition, Fat-free mass, Inflammation, Neonatal surgery, Neurodevelopment, Outcomes",

author = "Plummer, {Erin A.} and Qi Wang and Larson-Nath, {Catherine M.} and Scheurer, {Johannah M.} and Ramel, {Sara E.}",

note = "Funding Information: Funding for the project was from the Benjamin Walker Hanson Fund of the University of Minnesota Foundation and the Center for Neurobehavioral Development Seed Grant . The Center for Neurobehavioral Development at the University of Minnesota provided research space. Statistical analysis was performed through The Biostatistical Design and Analysis Center of The Clinical and Translational Science Institute of the University of Minnesota. Funding Information: The authors have no conflicts of interest to report. Funding for the project was from the Benjamin Walker Hanson Fund of the University of Minnesota Foundation and the Center for Neurobehavioral Development Seed Grant. ",

year = "2019",

month = feb,

doi = "10.1016/j.earlhumdev.2018.12.001",

language = "English (US)",

volume = "129",

pages = "5--10",

journal = "Early Human Development",

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T1 - Body composition and cognition in preschool-age children with congenital gastrointestinal anomalies

AU - Plummer, Erin A.

AU - Wang, Qi

AU - Larson-Nath, Catherine M.

AU - Scheurer, Johannah M.

AU - Ramel, Sara E.

N1 - Funding Information: Funding for the project was from the Benjamin Walker Hanson Fund of the University of Minnesota Foundation and the Center for Neurobehavioral Development Seed Grant . The Center for Neurobehavioral Development at the University of Minnesota provided research space. Statistical analysis was performed through The Biostatistical Design and Analysis Center of The Clinical and Translational Science Institute of the University of Minnesota. Funding Information: The authors have no conflicts of interest to report. Funding for the project was from the Benjamin Walker Hanson Fund of the University of Minnesota Foundation and the Center for Neurobehavioral Development Seed Grant.

PY - 2019/2

Y1 - 2019/2

N2 - Background: Children with congenital gastrointestinal anomalies (CGIAs) experience multiple stressors while hospitalized in neonatal intensive care units during an essential time of growth and development. Early stress and inadequate nutrition are linked to altered growth patterns and later neurodevelopmental delays. In other at-risk populations, improved fat-free mass (FFM) accretion is associated with improved cognitive outcomes. Objective: To determine if body composition is associated with cognitive function in preschool-age children with CGIAs. Study design: An observational study examined body composition and cognition in 34 preschool-age children with CGIAs. Anthropometric measurements and body composition testing via air displacement plethysmography were obtained. Measurements were compared with a reference group of healthy, term-born children. Cognition was measured with the NIH Toolbox Early Childhood Cognition Battery. Linear regression was used to test the association of body composition with cognitive function. Results: Compared with the reference group, children with CGIAs had similar anthropometric measurements (weight, height, and body mass index z-scores) and body composition at preschool-age. Processing speed scores were lower than standardized means (p = 0.001). Increased FFM was associated with higher receptive vocabulary scores (p = 0.001), cognitive flexibility scores (p = 0.005), and general cognitive function scores (p = 0.05). Conclusions: At preschool-age, children with CGIAs have similar growth and body composition to their peers. In children with CGIAs, higher FFM was associated with higher cognitive scores. Closer tracking of body composition and interventions aimed at increasing FFM may improve long-term outcomes in this population.

AB - Background: Children with congenital gastrointestinal anomalies (CGIAs) experience multiple stressors while hospitalized in neonatal intensive care units during an essential time of growth and development. Early stress and inadequate nutrition are linked to altered growth patterns and later neurodevelopmental delays. In other at-risk populations, improved fat-free mass (FFM) accretion is associated with improved cognitive outcomes. Objective: To determine if body composition is associated with cognitive function in preschool-age children with CGIAs. Study design: An observational study examined body composition and cognition in 34 preschool-age children with CGIAs. Anthropometric measurements and body composition testing via air displacement plethysmography were obtained. Measurements were compared with a reference group of healthy, term-born children. Cognition was measured with the NIH Toolbox Early Childhood Cognition Battery. Linear regression was used to test the association of body composition with cognitive function. Results: Compared with the reference group, children with CGIAs had similar anthropometric measurements (weight, height, and body mass index z-scores) and body composition at preschool-age. Processing speed scores were lower than standardized means (p = 0.001). Increased FFM was associated with higher receptive vocabulary scores (p = 0.001), cognitive flexibility scores (p = 0.005), and general cognitive function scores (p = 0.05). Conclusions: At preschool-age, children with CGIAs have similar growth and body composition to their peers. In children with CGIAs, higher FFM was associated with higher cognitive scores. Closer tracking of body composition and interventions aimed at increasing FFM may improve long-term outcomes in this population.

KW - Body composition

KW - Fat-free mass

KW - Inflammation

KW - Neonatal surgery

KW - Neurodevelopment

KW - Outcomes

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JF - Early Human Development

SN - 0378-3782

ER -

Body composition and cognition in preschool-age children with congenital gastrointestinal anomalies

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

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